C₁₀H₇ClFNO₂

Base Information

• Chemical Name: C₁₀H₇ClFNO₂
• CAS No.: 1126636-64-3
• Molecular Formula: C₁₀H₇ClFNO₂
• Molecular Weight: 227.622
• Mol file: 1126636-64-3.mol

Synonyms:C₁₀H₇ClFNO₂

Chemical Property of C₁₀H₇ClFNO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₇ClFNO₂

There total 4 articles about C₁₀H₇ClFNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propargyl alcohol (107-19-7) + 4-chloro-3-fluorobenzaldehyde oxime (202925-09-5) → C10H7ClFNO2 (1126636-64-3)

Guidance literature:

4-chloro-3-fluorobenzaldehyde oxime; With N-chloro-succinimide; In dichloromethane; Reflux;

propargyl alcohol; In dichloromethane; for 0.5h; Reflux;

With triethylamine; In dichloromethane; for 4h; Reflux;

DOI:10.1016/j.bmc.2016.08.066

Reference yield:

hydroxy-1-propyne (6175-54-8) + 4-chloro-3-fluorobenzaldehyde oxime (202925-09-5) → C10H7ClFNO2 (1126636-64-3)

Guidance literature:

hydroxy-1-propyne; 4-chloro-3-fluorobenzaldehyde oxime; With N-chloro-succinimide; In dichloromethane; for 0.5h; Reflux;

With triethylamine; In dichloromethane; for 4h; Reflux;

DOI:10.1016/j.bmcl.2017.04.039

Reference yield:

propargyl alcohol (107-19-7) + 4-chloro-3-fluorobenzoylchloride oxime (430534-91-1) → C10H7ClFNO2 (1126636-64-3)

Guidance literature:

With triethylamine; In toluene; at 25 ℃;

DOI:10.1016/j.bmcl.2011.01.051

upstream raw materials:

propargyl alcohol

4-chloro-3-fluorobenzoylchloride oxime

4-chloro-3-fluorobenzaldehyde

4-chloro-3-fluorobenzaldehyde oxime

Downstream raw materials:

C₁₀H₆Cl₂FNO₂

4-chloro-3-(4-chloro-3-fluorophenyl)isoxazole-5-carboxylic acid

4-chloro-3-(4-chloro-3-fluorophenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-5-carboxamide

C₁₂H₈Cl₂FNO₃

Refernces

• 1、 Pang, Guang Xian,Niu, Chao,Mamat, Nuramina,Aisa, Haji Akber. "Synthesis and in vitro biological evaluation of novel coumarin derivatives containing isoxazole moieties on melanin synthesis in B16 cells and inhibition on bacteria". . p. 2674 - 2677. Retrieved 2017/05/29.