1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE

Base Information Edit

Chemical Name:1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE
CAS No.:288573-56-8
Molecular Formula:C16H23 F N2 O2
Molecular Weight:294.369
Hs Code.:
Mol file:288573-56-8.mol

1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE

Synonyms:1-tert-Butoxycarbonyl-4-[(4-fluorophenyl)amino]piperidine;4-(4-Fluorophenylamino)piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-(4-fluoroanilino)-1-piperidinecarboxylate

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE Edit

Chemical Property:

Boiling Point:400.4±40.0 °C(Predicted)
PKA:5.09±0.20(Predicted)
PSA：41.57000
Density:1.159±0.06 g/cm3(Predicted)
LogP:3.64800

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE is a heterocyclic derivative and can be used as a pharmaceutical intermediate.

Technology Process of 1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE

There total 6 articles about 1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 371-40-4
4-fluoroaniline

: 288573-56-8
1-(tert-Butoxycarbonyl)-4-[(4-fluorophenyl)amino]piperidine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In dichloromethane; at 0 - 20 ℃; for 15h;

Reference yield: 66.0%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 460-00-4
1-Bromo-4-fluorobenzene

: 288573-56-8
1-(tert-Butoxycarbonyl)-4-[(4-fluorophenyl)amino]piperidine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 4h; Inert atmosphere;