C₁₆H₁₅BrO₃

Base Information

• Chemical Name: C₁₆H₁₅BrO₃
• CAS No.: 1226773-35-8
• Molecular Formula: C₁₆H₁₅BrO₃
• Molecular Weight: 335.197
• Mol file: 1226773-35-8.mol

Synonyms:C₁₆H₁₅BrO₃

Chemical Property of C₁₆H₁₅BrO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₅BrO₃

There total 2 articles about C₁₆H₁₅BrO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-(2-bromo-4-fluorophenyl)-1,3-dioxolane (773097-04-4) + benzyl alcohol (100-51-6,185532-71-2) → C16H15BrO3 (1226773-35-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 65 ℃; for 4h; Cooling; Inert atmosphere;

DOI:10.1021/jm101225g

Reference yield:

2-bromo-4-fluorobenzaldehyde (59142-68-6) → C16H15BrO3 (1226773-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 4 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 65 °C / Cooling; Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1021/jm101225g

Reference yield: 88.1%

C16H15BrO3 (1226773-35-8) → (5-(benzyloxy)-2-formylphenyl)boronic acid (1226773-36-9)

Guidance literature:

C₁₆H₁₅BrO₃; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; at -80 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; for 2h;

DOI:10.1021/jm101225g

upstream raw materials:

2-(2-bromo-4-fluorophenyl)-1,3-dioxolane

benzyl alcohol

2-bromo-4-fluorobenzaldehyde

Downstream raw materials:

(5-(benzyloxy)-2-formylphenyl)boronic acid

6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

6-hydroxyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

1,3-dihydro-1-hydroxy-2,2-benzoxaborol-6-yl N-phenylcarbamate

Refernces

• 1、 Ding, Dazhong,Meng, Qingqing,Gao, Guangwei,Zhao, Yaxue,Wang, Qing,Nare, Bakela,Jacobs, Robert,Rock, Fernando,Alley, Michael R. K.,Plattner, Jacob J.,Chen, Guoqiang,Li, Dawei,Zhou, Huchen. "Design, synthesis, and structure-activity relationship of trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents". experimental part. p. 1276 - 1287. Retrieved 2011/05/07.