4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid

Base Information

• Chemical Name: 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid
• CAS No.: 1593781-48-6
• Molecular Formula: C₁₄H₁₅NO₃S₂
• Molecular Weight: 309.41
• Mol file: 1593781-48-6.mol

Synonyms:4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid

Chemical Property of 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid

There total 3 articles about 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoate (1593781-46-4) → 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid (1593781-48-6)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 4h;

DOI:10.1002/chem.201303863

Reference yield:

methyl 4-(2-bromoacetyl)benzoate (56893-25-5) → 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid (1593781-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 8 h / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 0 - 20 °C

With lithium hydroxide monohydrate; In tetrahydrofuran; water; acetone;

DOI:10.1021/acs.inorgchem.7b02243

Reference yield:

methyl 4-acetylbenzoate (3609-53-8) → 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoic acid (1593781-48-6)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; N-Bromosuccinimide / acetonitrile / 4 h / 85 °C

2: acetone / 8 h / 20 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 0 - 20 °C

With N-Bromosuccinimide; lithium hydroxide monohydrate; toluene-4-sulfonic acid; In tetrahydrofuran; water; acetone; acetonitrile;

DOI:10.1021/acs.inorgchem.7b02243

upstream raw materials:

methyl 4-(2-((pyrrolidine-1-carbonothioyl)thio)acetyl)benzoate

methyl 4-acetylbenzoate

methyl 4-(2-bromoacetyl)benzoate

Refernces

• 1、 -. "Highly-sensitive reversible probe with cell permeability for Hg ions, and preparation method and application thereof". Paragraph 0020; 0022; 0029; 0030; 0031. . Retrieved 2019/01/05.