2-fluorobenzyl N-succinimidyl carbonate

Base Information

• Chemical Name: 2-fluorobenzyl N-succinimidyl carbonate
• CAS No.: 128595-02-8
• Molecular Formula: C₁₂H₁₀FNO₅
• Molecular Weight: 267.214
• Mol file: 128595-02-8.mol

Synonyms:2-fluorobenzyl N-succinimidyl carbonate

Chemical Property of 2-fluorobenzyl N-succinimidyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-fluorobenzyl N-succinimidyl carbonate

There total 2 articles about 2-fluorobenzyl N-succinimidyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

di(succinimido) carbonate (74124-79-1) + 2-fluorobenzyl alcohol (446-51-5) → 2-fluorobenzyl N-succinimidyl carbonate (128595-02-8)

Guidance literature:

With dmap; In dichloromethane; acetonitrile; for 6h; Ambient temperature;

DOI:10.1248/cpb.38.110

Reference yield:

→ 2-fluorobenzyl N-succinimidyl carbonate (128595-02-8)

Guidance literature:

Reference yield:

6-[cis-1-hydroxy-4-(methylamino)cyclohexyl]pyridin-3-ol + 2-fluorobenzyl N-succinimidyl carbonate (128595-02-8) → C28H28F2N2O6

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 18 - 25 ℃;

upstream raw materials:

di(succinimido) carbonate

2-fluorobenzyl alcohol

Downstream raw materials:

(2S,3aS,7aS)-1-2-(2-fluorobenzyloxycarbonyl)-L-lysyl-γ-D-glutamyl>octahydro-1H-indole-2-carboxylic acid

(S)-1-(2-(carboxymethoxy)-5-chlorophenyl)-5,6-difluoro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 2-fluorobenzyl ester

Refernces

• 1、 Sawayama,Tsukamoto,Sasagawa,Nishimura,Deguchi,Takeyama,Hosoki. "Angiotensin-converting enzyme inhibitors: Synthesis and biological activity of N-substituted tripeptide inhibitors". . p. 110 - 115. Retrieved 2007/10/02.