4-(3-Formylphenyl)phenol

Base Information

• Chemical Name: 4-(3-Formylphenyl)phenol
• CAS No.: 283147-95-5
• Molecular Formula: C₁₃H₁₀O₂
• Molecular Weight: 198.221
• Hs Code.: 2912499000
• European Community (EC) Number: 673-766-2
• DSSTox Substance ID: DTXSID50374728
• Nikkaji Number: J1.796.664B
• Wikidata: Q82163305
• Mol file: 283147-95-5.mol

Synonyms:4-(3-Formylphenyl)phenol;283147-95-5;3-(4-hydroxyphenyl)benzaldehyde;4'-Hydroxy-biphenyl-3-carbaldehyde;4'-hydroxybiphenyl-3-carbaldehyde;4'-hydroxy biphenyl-3-carbaldehyde;4'-Hydroxy-biphenyl-3-carboxaldehyde;[1,1'-Biphenyl]-3-carboxaldehyde, 4'-hydroxy-;SCHEMBL1885726;DTXSID50374728;OFJMZKYZSGGGPW-UHFFFAOYSA-N;MFCD04117372;4'-hydroxy biphenyl-3-carboxaldehyde;AKOS004116275;NCGC00374009-01;BS-25286;4'-Hydroxy-1,1'-biphenyl-3-carbaldehyde;4'-hydroxy[1,1'-biphenyl]-3-carbaldehyde;BB 0223342;CS-0212596;FT-0692507;F79745;A819408;4'-HYDROXY-[1,1'-BIPHENYL]-3-CARBALDEHYDE

Chemical Property of 4-(3-Formylphenyl)phenol

Chemical Property:

• PSA: 37.30000
• LogP: 2.87170
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 198.068079557
• Heavy Atom Count: 15
• Complexity: 207

Purity/Quality:

98%min ^*data from raw suppliers

4-(3-Formylphenyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)C2=CC=C(C=C2)O)C=O

Technology Process of 4-(3-Formylphenyl)phenol

There total 6 articles about 4-(3-Formylphenyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-phenol (106-41-2) + 3-Formylphenylboronic acid (87199-16-4) → 4'-hydroxy-[1,1'-biphenyl]-3-carbaldehyde (283147-95-5)

Guidance literature:

With sodium carbonate; palladium on activated charcoal; In ethanol; water; at 79 - 81 ℃; for 1h;

Reference yield: 74.0%

C36H38NO3Pol → 4'-hydroxy-[1,1'-biphenyl]-3-carbaldehyde (283147-95-5)

Guidance literature:

With ammonium cerium (IV) nitrate; In tetrahydrofuran; water; at 20 ℃; for 16h; solid phase reaction;

DOI:10.1039/b802204f

Reference yield: 70.0%

3-Formylphenylboronic acid (87199-16-4) → 4'-hydroxy-[1,1'-biphenyl]-3-carbaldehyde (283147-95-5)

Guidance literature:

3-Formylphenylboronic acid; polystyrene-Wang resin-CH₂O-(4-iodophenyl); With sodium carbonate; 1-butyl-3-methylimidazolium Tetrafluoroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 110 ℃; for 2h;

With trifluoroacetic acid; In dichloromethane; for 1h; Further stages.;

DOI:10.1021/ol0263292

upstream raw materials:

3-Formylphenylboronic acid

4-bromo-phenol

t-butyldimethylsilyl-4-bromophenol

C₁₁H₁₂BNO₅

Refernces

• 1、 -. "COMPOUNDS AND METHODS FOR PROMOTING PLANT GROWTH". Page/Page column 61. . Retrieved 2021/04/30.
• 2、 Davies, Stephen G.,Mortimer, Duncan A. B.,Mulvaney, Andrew W.,Russell, Angela J.,Skarphedinsson, Hjalmar,Smith, Andrew D.,Vickers, Richard J.. "An oxidatively-activated safety catch linker for solid phase synthesis". supporting information; experimental part. p. 1625 - 1634. Retrieved 2008/10/09.