3-Isocyanatopropanoylchloride

Base Information

• Chemical Name: 3-Isocyanatopropanoylchloride
• CAS No.: 3729-19-9
• Molecular Formula: C4H4 Cl N O2
• Molecular Weight: 133.534
• Hs Code.: 2929109000
• Mol file: 3729-19-9.mol

Synonyms:Isocyanicacid, 2-(chloroformyl)ethyl ester (7CI,8CI); Propionyl chloride, 3-isocyanato-(8CI); 2-(Chloroformyl)ethyl isocyanate; 3-Isocyanatopropanoyl chloride;3-Isocyanatopropionyl chloride

Chemical Property of 3-Isocyanatopropanoylchloride

Chemical Property:

• PSA: 46.50000
• LogP: 0.47770

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Isocyanatopropanoylchloride

There total 7 articles about 3-Isocyanatopropanoylchloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

phosgene (75-44-5) + 3-amino propanoic acid (107-95-9) → 3-Isocyanatopropanoylchlorid (3729-19-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; 1) 60-70 deg C, 6 h, 2) 60-90 deg C, 8 h;

Reference yield:

phosgene (75-44-5) + β-alanine hydrochloride (6057-90-5) → 3-Isocyanatopropanoylchlorid (3729-19-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/jo01339a030

Reference yield:

phosgene (75-44-5) + methyl 3-aminopropanoate hydrochloride (3196-73-4) → 2-methoxycarbonylethyl isocyanate (50835-77-3) + 3-Isocyanatopropanoylchlorid (3729-19-9)

Guidance literature:

methyl 3-aminopropanoate hydrochloride; With carbon dioxide; 1,1,1,3,3,3-hexamethyl-disilazane; for 5h; Heating;

phosgene; In toluene; at 25 ℃; Further stages.;

DOI:10.1134/S1070363206070115

upstream raw materials:

phosgene

β-alanine hydrochloride

N-Silyloxycarbonyl-β-alanin-trimethylsilylester

trichloromethyl chloroformate

Downstream raw materials:

chloro-trimethyl-silane

3-Isocyanato-propionic acid phenyl ester

3-Isocyanato-propionic acid 4-(3-isocyanato-propionyloxy)-butyl ester

3-<3-(4-Aethoxy-phenyl)-ureido>-propionsaeure-p-phenetidid

Refernces

• 1、 Mormann, Werner,Hoffmann, Silke,Hoffmann, Walter. "Synthesis and Stabilisation of Isocyanatoketenes". . p. 285 - 290. Retrieved 2007/10/02.