phenyl-(1-phenylethyl)phosphinic acid ethyl ester

Base Information

• Chemical Name: phenyl-(1-phenylethyl)phosphinic acid ethyl ester
• CAS No.: 461003-62-3
• Molecular Formula: C₁₆H₁₉O₂P
• Molecular Weight: 274.299
• Mol file: 461003-62-3.mol

Synonyms:phenyl-(1-phenylethyl)phosphinic acid ethyl ester

Chemical Property of phenyl-(1-phenylethyl)phosphinic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of phenyl-(1-phenylethyl)phosphinic acid ethyl ester

There total 1 articles about phenyl-(1-phenylethyl)phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Benzylphenylphosphinsaeureethylester (2129-79-5) + methyl iodide (74-88-4) → phenyl-(1-phenylethyl)phosphinic acid ethyl ester (461003-62-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1.) -70 deg C, 30 min, 2.) warm to room temperature;

DOI:10.1039/P19940003261

Reference yield: 67.0%

phenyl-(1-phenylethyl)phosphinic acid ethyl ester (461003-62-3) + methyl iodide (74-88-4) → (1-methyl-1-phenylethyl)(phenyl)phosphinic acid ethyl ester (461003-63-4)

Guidance literature:

phenyl-(1-phenylethyl)phosphinic acid ethyl ester; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 23 ℃; for 18h; Further stages.;

DOI:10.1021/jo0202839

Reference yield: 65.0%

phenyl-(1-phenylethyl)phosphinic acid ethyl ester (461003-62-3) → phenyl(1-phenylethyl)phosphinic acid (66577-36-4)

Guidance literature:

With hydrogenchloride; for 14h; Heating;

DOI:10.1039/P19940003261

upstream raw materials:

Benzylphenylphosphinsaeureethylester

methyl iodide

Downstream raw materials:

phenyl(1-phenylethyl)phosphinic acid

(1-methyl-1-phenylethyl)(phenyl)phosphinic acid ethyl ester

α-methylbenzyl(phenyl)phosphinic chloride

N-hydroxylamine

Refernces

• 1、 Ware Jr., Roy W.,Day, Cynthia S.,King, S. Bruce. "Diastereoselective and intramolecular cycloadditions of asymmetric P-nitroso phosphine oxides". . p. 6174 - 6180. Retrieved 2007/10/03.