5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime

Base Information

• Chemical Name: 5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime
• CAS No.: 90400-73-0
• Molecular Formula: C₁₇H₁₇NO₂
• Molecular Weight: 267.327
• Mol file: 90400-73-0.mol

Synonyms:5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime

Chemical Property of 5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime

There total 6 articles about 5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-one (90401-60-8) → 5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime (90400-73-0)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; for 12h; Heating;

DOI:10.1139/v88-088

Reference yield: 94.0%

5-benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-one (90401-60-8) → 5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime (90400-73-0)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In methanol; water; for 3h; Heating;

DOI:10.1248/cpb.32.130

Reference yield:

5-Hydroxy-1-tetralone (28315-93-7) → 5-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime (90400-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethylformamide / 4 h / 80 - 100 °C

2: 97 percent / NH₂OH*HCl, pyridine / 12 h / Heating

With pyridine; hydroxylamine hydrochloride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1139/v88-088

upstream raw materials:

5-benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-one

5-Hydroxy-1-tetralone

benzyl chloride

Downstream raw materials:

C₂₄H₂₃NO₄S

C₂₄H₂₃NO₄S

Refernces

• 1、 Itoh,Miyake,Tada,Hirata,Oka. "Synthesis and β-adrenergic blocking activity of 2-(N-substituted amino)-1,2,3,4-tetrahydronaphthalen-1-ol derivatives". . p. 130 - 151. Retrieved 2007/10/02.