2,2',4,4'-Tetramethoxybenzophenone

Base Information

• Chemical Name: 2,2',4,4'-Tetramethoxybenzophenone
• CAS No.: 3555-85-9
• Molecular Formula: C17H18 O5
• Molecular Weight: 302.327
• Hs Code.: 2914509090
• DSSTox Substance ID: DTXSID60355684
• Nikkaji Number: J1.596.077I
• Wikidata: Q82134710
• Mol file: 3555-85-9.mol

Synonyms:bis(2,4-dimethoxyphenyl)methanone;2,2',4,4'-Tetramethoxybenzophenone;3555-85-9;CBMicro_021652;Oprea1_419629;Oprea1_754627;SCHEMBL285924;Bis(2,4-dimethoxyphenyl) ketone;DTXSID60355684;HMS1678O10;CCG-8955;AKOS000513777;BIM-0021525.P001;2,2',4,4'-Tetramethoxybenzophenone, 97%;SR-01000315301;SR-01000315301-1

Chemical Property of 2,2',4,4'-Tetramethoxybenzophenone

Chemical Property:

• Melting Point: 138-142 °C(lit.)
• PSA: 53.99000
• LogP: 2.95200
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 302.11542367
• Heavy Atom Count: 22
• Complexity: 327

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)C2=C(C=C(C=C2)OC)OC)OC

Technology Process of 2,2',4,4'-Tetramethoxybenzophenone

There total 23 articles about 2,2',4,4'-Tetramethoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

[(bromodifluoromethyl)sulfanyl]benzene (78031-08-0) + 1,3-Dimethoxybenzene (151-10-0) → S-phenyl 2,4-dimethoxybenzenecarbothioate (1352811-99-4) + 2,2',4,4'-tetramethoxybenzophenone (3555-85-9)

Guidance literature:

[(bromodifluoromethyl)sulfanyl]benzene; With titanium tetrachloride; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

1,3-Dimethoxybenzene; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.201100715

Reference yield: 79.0%

2,2',4,4'-tetrahydroxybenzophenone (131-55-5) + methyl iodide (74-88-4) → 2,2',4,4'-tetramethoxybenzophenone (3555-85-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm049916x

Reference yield: 69.0%

carbon monoxide (201230-82-2) + 2,4-dimethoxyphenyllead triacetate (36896-61-4) → 2,2',4,4'-tetramethoxybenzophenone (3555-85-9)

Guidance literature:

With sodium methylate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In chloroform; at 20 ℃; for 3h; under 760 Torr;

DOI:10.1081/SCC-100103533

upstream raw materials:

2,2',4,4'-tetrahydroxybenzophenone

diethyl ether

1-Bromo-2,4-dimethoxybenzene

phenyllithium

Downstream raw materials:

1,1-bis(2',4'-dimethoxyphenyl)ethylene

C₁₉H₂₄N₂O₄

C₆H₃(OCH₃)2COC₆H₃(OCH₃)OBF₂

2,2',4,4'-tetrahydroxybenzophenone

Refernces

• 1、 Liu, Chaomei,Zhang, Mei,Zhang, Zhenhuan,Zhang, Steven B.,Yang, Shanmin,Zhang, Amy,Yin, Liangjie,Swarts, Steven,Vidyasagar, Sadasivan,Zhang, Lurong,Okunieff, Paul. "Synthesis and anticancer potential of novel xanthone derivatives with 3,6-substituted chains". . p. 4263 - 4271. Retrieved 2016/08/23.
• 2、 Abusalim, Deyaa I.,Merfeld, Michelle L.,Lash, Timothy D.. "Dicarbaporphyrinoid systems. Synthesis of oxo-adj-dibenziphlorins". . p. 10360 - 10368. Retrieved 2013/11/06.