Piperidine-1-sulfonyl Chloride

Base Information

• Chemical Name: Piperidine-1-sulfonyl Chloride
• CAS No.: 35856-62-3
• Molecular Formula: C5H10 Cl N O2 S
• Molecular Weight: 183.659
• Hs Code.: 2933399090
• European Community (EC) Number: 694-736-5
• DSSTox Substance ID: DTXSID50461561
• Nikkaji Number: J2.008.011F
• Wikidata: Q82285930
• Mol file: 35856-62-3.mol

Synonyms:Piperidine-1-sulfonyl Chloride;35856-62-3;1-Piperidinesulfonyl chloride;1-Piperidinesulfonylchloride;Piperidinsulfochlorid;piperidinesulfonyl chloride;piperidinosulfonyl chloride;Pperdne-1-sulfonyl chlorde;(piperidinyl)sulfonyl chloride;SCHEMBL417152;1-piperidine sulfonyl chloride;DTXSID50461561;QQJYAXDCMMXECR-UHFFFAOYSA-N;AMY16256;BCP24084;MFCD03250329;Piperidine-1-sulfonyl chloride, 95%;Piperidine-1-sulfonyl chloride, 96%;AKOS000263715;CS-W019289;SB41084;BS-13219;BB 0220681;FT-0678021;EN300-28609;J-523972;F0001-1030;Z228588474

Chemical Property of Piperidine-1-sulfonyl Chloride

Chemical Property:

• Vapor Pressure: 0.00547mmHg at 25°C
• Refractive Index: 1.533
• Boiling Point: 120℃ (10 Torr)
• PKA: -8.25±0.20(Predicted)
• Flash Point: 119.6°C
• PSA: 45.76000
• Density: 1.308 g/mL at 25 °C
• LogP: 1.97460
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Moisture Sensitive
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 183.0120774
• Heavy Atom Count: 10
• Complexity: 190

Purity/Quality:

98%,99%, ^*data from raw suppliers

Piperidine-1-sulfonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)S(=O)(=O)Cl
• Uses: Piperidine-1-sulfonyl chloride is used as pharmaceutical intermediate.

Technology Process of Piperidine-1-sulfonyl Chloride

There total 8 articles about Piperidine-1-sulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

piperidine (110-89-4) → 1-piperidinesulfonyl chloride (35856-62-3)

Guidance literature:

With sulfuryl dichloride; at 0 - 60 ℃; for 5h;

DOI:10.1007/s00044-021-02802-w

Reference yield: 62.0%

piperidine (110-89-4) → 1-piperidinesulfonyl chloride (35856-62-3) + piperidine hydrochloride (6091-44-7)

Guidance literature:

With 4-methylphenyl chlorosulfate; 2,6-diisopropylphenyl chlorosulfate; at -78 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.1021/ja405949a

Reference yield:

sodium; piperidine-1-sulfonate → 1-piperidinesulfonyl chloride (35856-62-3)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; at 80 ℃; for 18h;

DOI:10.1016/j.bmcl.2004.03.089

upstream raw materials:

piperidine

phenylchlorosulfate

N-chloropiperidine

piperidine hydrochloride

Downstream raw materials:

2-[tert-butoxycarbonyl-(piperidine-1-sulfonylamino)-methyl]-5,5-dimethyl-thiazolidine-4-carboxylic acid benzyl ester

N-(4-phenylphenoxysulfonyl)-piperidine

N-(phenoxysulfonyl)-piperidine

(1S,2S)-N-(piperidyl-N-sulfonyl)-1,2-diphenylethylenediamine

Refernces

• 1、 Padma, D. K.,Bhat, V. Subrahmanya,Murthy, A. R. Vasudeva. "REACTIONS OF SULPHURYL FLUORIDE, SULPHURYL CHLOROFLUORIDE AND SULPHURYL CHLORIDE WITH AMINES". . p. 425 - 438. Retrieved 1982.
• 2、 Matsuo, Kasumi,Kuriyama, Masami,Yamamoto, Kosuke,Demizu, Yosuke,Nishida, Koyo,Onomura, Osamu. "Nickel-Catalyzed Hydrodeoxygenation of Aryl Sulfamates with Alcohols as Mild Reducing Agents". . p. 4449 - 4460. Retrieved 2021/08/25.
• 3、 -. "Triazole compounds and their use in agriculture (by machine translation)". Paragraph 0438; 0439; 0440; 0442; 0444. . Retrieved 2018/11/04.