3,5-Dibromo-2,6-dimethylpyridine

Base Information

• Chemical Name: 3,5-Dibromo-2,6-dimethylpyridine
• CAS No.: 3430-34-0
• Molecular Formula: C7H7Br2N
• Molecular Weight: 264.947
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10355770
• Wikidata: Q72469757
• Mol file: 3430-34-0.mol

Synonyms:3,5-dibromo-2,6-dimethylpyridine;3430-34-0;2,6-DIMETHYL-3,5-DIBROMOPYRIDINE;MFCD00234282;Pyridine, 3,5-dibromo-2,6-dimethyl-;SCHEMBL2258481;DTXSID10355770;3,5-dibromo-2,6-dimethlpyridine;BBL101832;STL555629;AKOS008901089;CS-W006812;AS-32858;SY059517;3,5-bis(bromanyl)-2,6-dimethyl-pyridine;FT-0646137;A822161;AC-907/25004637;J-511249

Chemical Property of 3,5-Dibromo-2,6-dimethylpyridine

Chemical Property:

• Melting Point: 46-57 °C
• Boiling Point: 240.2 °C at 760 mmHg
• PKA: 1.96±0.20(Predicted)
• Flash Point: 99.1 °C
• PSA: 12.89000
• Density: 1.795 g/cm³
• LogP: 3.22340
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 264.89247
• Heavy Atom Count: 10
• Complexity: 106

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dibromo-2,6-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C(=N1)C)Br)Br

Technology Process of 3,5-Dibromo-2,6-dimethylpyridine

There total 5 articles about 3,5-Dibromo-2,6-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,6-dimethyl-3-amino-5-bromopyridine → 3,5-dibromo-2,6-dimethylpyridine (3430-34-0)

Guidance literature:

2,6-dimethyl-3-amino-5-bromopyridine; With hydrogen bromide; copper(I) bromide; at 0 ℃; for 0.25h;

With sodium nitrite; for 3h; Temperature; Concentration;

Reference yield: 61.0%

2,6-dimethylpyridine (108-48-5) → 3-bromo-2,6-dimethylpyridine (3430-31-7) + 3,5-dibromo-2,6-dimethylpyridine (3430-34-0)

Guidance literature:

With sulfuric acid; bromine; at 155 - 175 ℃; for 24h;

Reference yield:

2,6-dimethylpyridin-3-amine (3430-33-9) → 3,5-dibromo-2,6-dimethylpyridine (3430-34-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Reflux

2.1: bromine / 2.5 h / 23 - 48 °C

3.1: hydrogen bromide; copper(I) bromide / 0.25 h / 0 °C

3.2: 3 h

With hydrogen bromide; bromine; copper(I) bromide;

upstream raw materials:

2,6-dimethylpyridine

2,6-dimethylpyridin-3-amine

Downstream raw materials:

2,6-dimethyl-3,5-diphenylpyridine

2,6-dimethyl-3-phenylpyridine

Refernces

• 1、 -. "Synthetic method of 2,6-dimethyl-3,5-dibromopyridine". . . Retrieved 2017/11/30.