2,6-dimethyl-3,5-diphenylpyridine

Base Information

• Chemical Name: 2,6-dimethyl-3,5-diphenylpyridine
• CAS No.: 65907-81-5
• Molecular Formula: C19H17N
• Molecular Weight: 259.345
• Mol file: 65907-81-5.mol

Synonyms:

Chemical Property of 2,6-dimethyl-3,5-diphenylpyridine

Chemical Property:

• Vapor Pressure: 3.54E-05mmHg at 25°C
• Boiling Point: 364.4°Cat760mmHg
• Flash Point: 154.2°C
• Density: 1.055g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-dimethyl-3,5-diphenylpyridine

There total 14 articles about 2,6-dimethyl-3,5-diphenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,5-dibromo-2,6-dimethylpyridine (3430-34-0) + phenylboronic acid (98-80-6) → 2,6-dimethyl-3,5-diphenylpyridine (65907-81-5)

Guidance literature:

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; benzene; at 80 ℃; for 24h;

DOI:10.1055/s-2006-942535

Reference yield: 84.0%

3-bromo-2,6-dimethyl-5-phenylpyridine (915946-54-2) + phenylboronic acid (98-80-6) → 2,6-dimethyl-3,5-diphenylpyridine (65907-81-5)

Guidance literature:

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; benzene; at 80 ℃; for 24h;

DOI:10.1055/s-2006-942535

Reference yield: 69.0%

methylamine hydrochloride (593-51-1) + 1-phenyl-acetone (103-79-7,136675-26-8) → methamphetamin (7632-10-2) + 2,6-dimethyl-3,5-diphenylpyridine (65907-81-5) + 3-phenyl-2-propanol (698-87-3,14898-87-4) + N-benzoylmethamphetamine (73355-87-0) + N-(1-methyl-2-phenylethyl)benzamide (70631-05-9,1795-95-5) + N-acetylmethamphetamine (27765-80-6) + N-formylmethamphetamine (42932-20-7,26343-75-9,894793-16-9) + N-(β-phenylisopropyl)benzyl(methyl)ketimine (74917-80-9) + 2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2) + 3,4-diphenylbut-3-en-2-one (1722-69-6)

Guidance literature:

With aluminum amalgam; sodium hydroxide; In methanol; at -10 - 60 ℃; for 1.5h;

DOI:10.1021/ac9005588

upstream raw materials:

3-bromo-2,6-dimethyl-5-phenylpyridine

phenylboronic acid

3,5-dibromo-2,6-dimethylpyridine

3,5-dibromo-4-chloro-2,6-dimethyl-pyridine

Refernces

• 1、 Kunalan, Vanitha,Daeid, Niamh Nic,Kerr, William J.,Buchanan, Hilary A. S.,McPherson, Allan R.. "Characterization of route specific impurities found in methamphetamine synthesized by the Leuckart and reductive amination methods". experimental part. p. 7342 - 7348. Retrieved 2010/04/06.