C₁₃H₁₆FNO₄

Base Information

• Chemical Name: C₁₃H₁₆FNO₄
• CAS No.: 1620450-65-8
• Molecular Formula: C₁₃H₁₆FNO₄
• Molecular Weight: 269.273
• Mol file: 1620450-65-8.mol

Synonyms:C₁₃H₁₆FNO₄

Chemical Property of C₁₃H₁₆FNO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₆FNO₄

There total 4 articles about C₁₃H₁₆FNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C13H16FNO4 (1620450-64-7) → C13H16FNO4 (1620450-65-8) + C13H16FNO4 (1620450-66-9)

Guidance literature:

With Chiralpak AD-3 150x4.6 mm I_.D; In carbon dioxide; diethylamine; isopropyl alcohol; Resolution of racemate; liquid CO₂;

Reference yield:

C13H16(2)HNO4 (1620450-68-1) → C13H16FNO4 (1620450-65-8) + C13H16FNO4 (1620450-66-9)

Guidance literature:

With Chiralpak IC; In isopropyl alcohol; Resolution of racemate;

Reference yield:

2-amino-3-fluoro-3-methylbutanoic acid (43163-94-6) + benzyl chloroformate (501-53-1,94274-21-2) → C13H16FNO4 (1620450-65-8) + C13H16FNO4 (1620450-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 15 h / 0 - 25 °C

2: Chiralpak AD-3 150x4.6 mm I_.D / isopropyl alcohol; carbon dioxide; diethylamine / Resolution of racemate; liquid CO₂

With triethylamine; In methanol; carbon dioxide; diethylamine; isopropyl alcohol;

upstream raw materials:

2-amino-3-fluoro-3-methylbutanoic acid

benzyl chloroformate

C₁₃H₁₆FNO₄

DL-<3-(2)H>-valine

Refernces

• 1、 -. "THIAZOLYL-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES". . . Retrieved 2014/08/06.