5-chloro-3-fluoro-2-hydrazinylpyridine

Base Information

• Chemical Name: 5-chloro-3-fluoro-2-hydrazinylpyridine
• CAS No.: 248255-70-1
• Molecular Formula: C5H5 Cl F N3
• Molecular Weight: 161.566
• Hs Code.: 2933990090
• Mol file: 248255-70-1.mol

Synonyms:2(1H)-Pyridinone,5-chloro-3-fluoro-, hydrazone (9CI); 2-Hydrazino-3-fluoro-5-chloropyridine

Chemical Property of 5-chloro-3-fluoro-2-hydrazinylpyridine

Chemical Property:

• Melting Point: 173-174 °C(Solv: ethanol (64-17-5))
• Boiling Point: 172.4±50.0 °C(Predicted)
• PKA: 7.79±0.70(Predicted)
• PSA: 50.94000
• Density: 1.57±0.1 g/cm3(Predicted)
• LogP: 1.93300
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-3-fluoro-2-hydrazinylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-3-fluoro-2-hydrazinylpyridine

There total 1 articles about 5-chloro-3-fluoro-2-hydrazinylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-chloro-2,3-difluoropyridine (89402-43-7) → 5-chloro-3-fluoro-2-hydrazinylpyridine (248255-70-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 20h; Heating;

DOI:10.1002/chem.200400837

Reference yield: 72.0%

5-chloro-3-fluoro-2-hydrazinylpyridine (248255-70-1) → 3-chloro-5-fluoro-pyridine (514797-99-0)

Guidance literature:

With copper(II) sulfate; Heating;

DOI:10.1002/chem.200400837

Reference yield:

5-chloro-3-fluoro-2-hydrazinylpyridine (248255-70-1) → 3-Fluoropyridine (372-47-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 72 percent / aq. CuSO₄ / Heating

2.1: BuLi / tetrahydrofuran; hexane

2.2: 78 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane

3.1: 71 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 6 h / 125 °C

4.1: HCOONH₄ / Pd/C / octan-1-ol / 6 h / 45 °C

With potassium fluoride; n-butyllithium; ammonium formate; tetramethlyammonium chloride; copper(II) sulfate; palladium on activated charcoal; In tetrahydrofuran; octanol; hexane; dimethyl sulfoxide;

DOI:10.1002/chem.200400837

upstream raw materials:

5-chloro-2,3-difluoropyridine

Downstream raw materials:

3-chloro-5-fluoro-pyridine

3,4-difluoropyridine

3-chloro-4,5-difluoropyridine

3,4-dichloro-5-fluoropyridine

Refernces

• 1、 -. "Process for preparing 2-aminopyridine derivatives". Page/Page column 3-4. . Retrieved 2008/06/13.