3-Chloro-4,5-difluoropyridine

Base Information

• Chemical Name: 3-Chloro-4,5-difluoropyridine
• CAS No.: 851178-98-8
• Molecular Formula: C5H2ClF2N
• Molecular Weight: 149.527
• Mol file: 851178-98-8.mol

Synonyms:3-Chloro-4,5-difluoropyridine

Chemical Property of 3-Chloro-4,5-difluoropyridine

Chemical Property:

• Vapor Pressure: 9.29mmHg at 25°C
• Refractive Index: 1.479
• Boiling Point: 136 °C at 760 mmHg
• Flash Point: 36.1 °C
• PSA: 12.89000
• Density: 1.451g/cm³
• LogP: 2.01320

Purity/Quality:

99% ^*data from raw suppliers

3-CHLORO-4,5-DIFLUOROPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-4,5-difluoropyridine

There total 4 articles about 3-Chloro-4,5-difluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3,4-dichloro-5-fluoropyridine (851179-02-7) → 3-chloro-4,5-difluoropyridine (851178-98-8)

Guidance literature:

With potassium fluoride; tetramethlyammonium chloride; In dimethyl sulfoxide; at 125 ℃; for 6h;

DOI:10.1002/chem.200400837

Reference yield:

5-chloro-3-fluoro-2-hydrazinylpyridine (248255-70-1) → 3-chloro-4,5-difluoropyridine (851178-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 72 percent / aq. CuSO₄ / Heating

2.1: BuLi / tetrahydrofuran; hexane

2.2: 78 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane

3.1: 71 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 6 h / 125 °C

With potassium fluoride; n-butyllithium; tetramethlyammonium chloride; copper(II) sulfate; In tetrahydrofuran; hexane; dimethyl sulfoxide;

DOI:10.1002/chem.200400837

Reference yield:

5-chloro-2,3-difluoropyridine (89402-43-7) → 3-chloro-4,5-difluoropyridine (851178-98-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 87 percent / hydrazine monohydrate / ethanol / 20 h / Heating

2.1: 72 percent / aq. CuSO₄ / Heating

3.1: BuLi / tetrahydrofuran; hexane

3.2: 78 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane

4.1: 71 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 6 h / 125 °C

With potassium fluoride; n-butyllithium; tetramethlyammonium chloride; hydrazine hydrate; copper(II) sulfate; In tetrahydrofuran; ethanol; hexane; dimethyl sulfoxide;

DOI:10.1002/chem.200400837

upstream raw materials:

3,4-dichloro-5-fluoropyridine

5-chloro-3-fluoro-2-hydrazinylpyridine

5-chloro-2,3-difluoropyridine

3-chloro-5-fluoro-pyridine

Downstream raw materials:

3,4-difluoropyridine

3-Fluoropyridine

4-chloro-3-fluoro-pyridine

Refernces