248255-70-1

Basic information

• Product Name: 5-chloro-3-fluoro-2-hydrazinylpyridine
• Synonyms: 5-Chloro-3-fluoro-2-hydrazinylpyridine
• CAS NO: 248255-70-1
• Molecular Formula: C₅H₅ClFN₃
• Molecular Weight: 161.56
• Mol File: 248255-70-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 173-174 °C(Solv: ethanol (64-17-5))
• Boiling Point: 172.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.57±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.79±0.70(Predicted)
• CAS DataBase Reference: 5-chloro-3-fluoro-2-hydrazinylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-fluoro-2-hydrazinylpyridine(248255-70-1)
• EPA Substance Registry System: 5-chloro-3-fluoro-2-hydrazinylpyridine(248255-70-1)

Safety Data

• Hazardous Substances Data: 248255-70-1(Hazardous Substances Data)

Usage

General Description

5-Chloro-3-fluoro-2-hydrazinylpyridine is a chemical compound with the molecular formula C5H4ClFN4. It is a hydrazine derivative that contains a pyridine ring with a chloro and fluoro substituent as well as a hydrazinyl functional group. 5-chloro-3-fluoro-2-hydrazinylpyridine is often used in the synthesis of various pharmaceuticals and agrochemicals. It has shown potential as a building block for the development of new drugs due to its ability to target specific biological pathways. Additionally, it has been studied for its potential antimicrobial and antitumor activities. Overall, 5-chloro-3-fluoro-2-hydrazinylpyridine is a versatile chemical with potential applications in the fields of medicine and agriculture.

Upstream product

• 89402-43-7 5-chloro-2,3-difluoropyridine 

Downstream Products

• 246847-98-3 5-chloro-3-fluoro-pyridine-2-amine 
• 2546-56-7 4-chloro-3-fluoro-pyridine 
• 372-47-4 3-Fluoropyridine 
• 851179-02-7 3,4-dichloro-5-fluoropyridine 
• 851178-98-8 3-chloro-4,5-difluoropyridine 
• 82878-63-5 3,4-difluoropyridine 
• 514797-99-0 3-chloro-5-fluoro-pyridine 

Relevant articles and documents

IMIDAZOLE AND TRIAZOLE CONTAINING BICYCLIC COMPOUNDS AS JAK INHIBITORS

The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides pharmaceutical compo

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.