3-CHLORO-6-METHYL-BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE

Base Information

• Chemical Name: 3-CHLORO-6-METHYL-BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE
• CAS No.: 34576-87-9
• Molecular Formula: C10H6Cl2OS
• Molecular Weight: 245.129
• Hs Code.: 2934999090
• Mol file: 34576-87-9.mol

Synonyms:3-Chloro-6-methylbenzo[b]thiophene-2-carbonylchloride;

Chemical Property of 3-CHLORO-6-METHYL-BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE

Chemical Property:

• Boiling Point: 357.606 °C at 760 mmHg
• Flash Point: 170.074 °C
• PSA: 45.31000
• Density: 1.462 g/cm³
• LogP: 4.24210
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-6-methyl-1-benzothiophene-2-carbonyl chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: 8:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-6-METHYL-BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE

There total 5 articles about 3-CHLORO-6-METHYL-BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2Z)-3-(4-methylphenyl)propenoic acid (14290-88-1,940-61-4) → 3-Chlor-6-methyl-benzo--thiophen-2-carbonsaeurechlorid (34576-87-9)

Guidance literature:

With pyridine; thionyl chloride; at 140 ℃; for 0.5h;

Reference yield: 72.0%

trans-p-methylcinnamic acid (1866-39-3,940-61-4) → 3-Chlor-6-methyl-benzo--thiophen-2-carbonsaeurechlorid (34576-87-9)

Guidance literature:

With thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; at 140 ℃; for 3h;

DOI:10.1007/BF00506608

Reference yield: 55.0%

α-Brom-p-methyl-hydrozimtsaeure (7141-87-9) → 3-Chlor-6-methyl-benzo--thiophen-2-carbonsaeurechlorid (34576-87-9)

Guidance literature:

With thionyl chloride; N-benzyl-N-methylmorpholinium chloride; at 140 ℃; for 2.5h;

DOI:10.1023/A:1026190103546

upstream raw materials:

(2Z)-3-(4-methylphenyl)propenoic acid

trans-p-methylcinnamic acid

α-Brom-p-methyl-hydrozimtsaeure

4-methylcinnamic acid

Downstream raw materials:

methyl 3-chloro-6-methylbenzothiophene-2-carboxylate

N-(4-carboxyphenyl)-6-methyl-3-chlorobenzo[b]thiophene-2-carboxamide

6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide

N-(4-chlorocarbonylphenyl)-6-methyl-3-chlorobenzo[b]thiophene-2-carboxamide

Refernces

• 1、 Obushak,Matiichuk,Martyak. "Synthesis of heterocycles from the products of anionic arylation of unsaturated compounds. 7*. Products of haloarylation of acrylic acid and its esters in the synthesis of benzo[b]thiophene derivatives". . p. 878 - 884. Retrieved 2007/10/03.
• 2、 -. "Process for the synthesis of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides". . . Retrieved 2008/06/13.