Technology Process of 2-(cyclohex-1-en-1-ylethynyl)aniline
There total 5 articles about 2-(cyclohex-1-en-1-ylethynyl)aniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; triethylamine; triphenylphosphine;
palladium dichloride;
at 20 ℃;
for 24h;
DOI:10.1016/S0040-4020(03)00073-5
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
at 20 ℃;
for 2h;
Sealed tube;
Inert atmosphere;
DOI:10.1021/acs.orglett.0c04186
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
2.1: pyridine; trichlorophosphate / 2 h / 0 - 20 °C / Inert atmosphere
3.1: potassium carbonate / tetrahydrofuran; methanol / 2 h / 20 °C / Inert atmosphere
4.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / 20 °C / Inert atmosphere
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; potassium carbonate; triethylamine; trichlorophosphate;
In
tetrahydrofuran; methanol; hexane;
4.1: |Sonogashira Cross-Coupling;
DOI:10.1002/adsc.201800509