ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE
• CAS No.: 177760-52-0
• Molecular Formula: C6H8N2O3
• Molecular Weight: 156.141
• Hs Code.: 29349990
• Mol file: 177760-52-0.mol

Synonyms:2-Aminooxazole-4-carboxylic acid ethyl ester;

Chemical Property of ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 124-128 °C
• Refractive Index: 1.523
• Boiling Point: 282.939 °C at 760 mmHg
• PKA: 2.82±0.10(Predicted)
• Flash Point: 124.918 °C
• PSA: 78.35000
• Density: 1.278 g/cm³
• LogP: 1.01470
• Storage Temp.: Keep Cold

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4-oxazolecarboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2-aminooxazole-4-carboxylate is an intermediate used in the preparation of inhibitors of Akt activity useful in the treatment of cancer and arthritis.

Technology Process of ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE

There total 2 articles about ETHYL 2-AMINOOXAZOLE-4-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

ethyl Bromopyruvate (70-23-5) + urea (57-13-6) → ethyl 2-aminooxazole-4-carboxylate (177760-52-0)

Guidance literature:

In ethanol; for 12h; Reflux;

Reference yield:

ethyl 2-oxo-3-chloropropionate (65868-37-3) + urea (57-13-6) → ethyl 2-aminooxazole-4-carboxylate (177760-52-0)

Guidance literature:

In ethanol; Heating;

DOI:10.1055/s-1999-2819

Reference yield: 100.0%

ethyl 2-aminooxazole-4-carboxylate (177760-52-0) + benzoyl chloride (98-88-4) → C13H12N2O4

Guidance literature:

ethyl 2-aminooxazole-4-carboxylate; With dmap; In dichloromethane; for 0.166667h;

benzoyl chloride; In dichloromethane; at 50 ℃; for 12h;

DOI:10.1016/j.bioorg.2020.103988

upstream raw materials:

ethyl Bromopyruvate

urea

ethyl 2-oxo-3-chloropropionate

Downstream raw materials:

2-(3-benzyl-ureido)-oxazole-4-carboxylic acid ethyl ester

ethyl 2-chloro-1,3-oxazole-4-carboxylate

2-bromo-4-(ethoxycarbonyl)-1,3-oxazol-5-ylium

ethyl 2,5-dibromooxazole-4-carboxylate

Refernces

• 1、 de Gaetano, Monica,Butler, Eibhlín,Gahan, Kevin,Zanetti, Andrea,Marai, Mariam,Chen, Jianmin,Cacace, Antonino,Hams, Emily,Maingot, Catherine,McLoughlin, Alisha,Brennan, Eoin,Leroy, Xavier,Loscher, Christine E.,Fallon, Padraic,Perretti, Mauro,Godson, Catherine,Guiry, Patrick J.. "Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)". . p. 80 - 108. Retrieved 2018/11/21.
• 2、 -. "HETEROCYCLIC COMPOUND". Paragraph 0601. . Retrieved 2015/01/18.