Ethyl 2-bromo-1,3-oxazole-4-carboxylate

Base Information

• Chemical Name: Ethyl 2-bromo-1,3-oxazole-4-carboxylate
• CAS No.: 460081-20-3
• Molecular Formula: C6H6BrNO3
• Molecular Weight: 220.023
• Hs Code.: 2934999090
• Mol file: 460081-20-3.mol

Synonyms:Ethyl2-bromo-1,3-oxazole-4-carboxylate;Ethyl 2-bromooxazole-4-carboxylate;

Chemical Property of Ethyl 2-bromo-1,3-oxazole-4-carboxylate

Chemical Property:

• Vapor Pressure: 0.00616mmHg at 25°C
• Refractive Index: 1.51
• Boiling Point: 272.2 °C at 760 mmHg
• PKA: -3.20±0.10(Predicted)
• Flash Point: 118.4 °C
• PSA: 52.33000
• Density: 1.617 g/cm³
• LogP: 1.61380
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl2-Bromooxazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

• Uses: Ethyl 2-Bromooxazole-4-carboxylate, is a building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be utilized for the synthesis of C(2)-C(4'') linked poly-oxazoles.

Technology Process of Ethyl 2-bromo-1,3-oxazole-4-carboxylate

There total 3 articles about Ethyl 2-bromo-1,3-oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-chloro-1,3-oxazole-4-carboxylate (460081-18-9) → 2-bromo-4-(ethoxycarbonyl)-1,3-oxazol-5-ylium (460081-20-3)

Guidance literature:

With trimethylsilyl bromide; at 85 ℃; for 72h;

DOI:10.1002/ejoc.201900032

Reference yield: 21.0%

ethyl 2-aminooxazole-4-carboxylate (177760-52-0) → 2-bromo-4-(ethoxycarbonyl)-1,3-oxazol-5-ylium (460081-20-3) + ethyl 2,5-dibromooxazole-4-carboxylate (460081-22-5,862731-70-2)

Guidance literature:

With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 80 ℃;

DOI:10.1021/ol0262800

Reference yield:

ethyl 2-aminooxazole-4-carboxylate (177760-52-0) → 2-bromo-4-(ethoxycarbonyl)-1,3-oxazol-5-ylium (460081-20-3)

Guidance literature:

With copper(ll) bromide; isopentyl nitrite; In acetonitrile; at 60 ℃;

DOI:10.1016/j.bmcl.2008.03.018

upstream raw materials:

ethyl 2-aminooxazole-4-carboxylate

ethyl 2-chloro-1,3-oxazole-4-carboxylate

Downstream raw materials:

ethyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-oxazole-4-carboxylate

C₁₃H₁₀F₃NO₄

ethyl 2-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenyl)oxazole-4-carboxylate

2-bromooxazole-4-carbaldehyde

Refernces

• 1、 Hall, Adrian,Billinton, Andy,Brown, Susan H.,Chowdhury, Anita,Giblin, Gerard M.P.,Goldsmith, Paul,Hurst, David N.,Naylor, Alan,Patel, Sadhana,Scoccitti, Tiziana,Theobald, Pamela J.. "Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping". . p. 2684 - 2690. Retrieved 2008/12/21.