Technology Process of ethyl 2-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenyl)oxazole-4-carboxylate
There total 5 articles about ethyl 2-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenyl)oxazole-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
1,2-dimethoxyethane; water;
at 85 ℃;
for 24h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrahydrofuran / 2 h / 20 °C
2: potassium hydroxide / methanol / 12 h / Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 45 °C
4: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate; potassium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C
1.2: 1 h / 20 °C
2.1: tetrahydrofuran / 2 h / 20 °C
3.1: potassium hydroxide / methanol / 12 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 45 °C
5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;