8-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 8-methoxy-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 34146-68-4
• Molecular Formula: C10H13NO
• Molecular Weight: 163.22
• Hs Code.: 2933499090
• Mol file: 34146-68-4.mol

Synonyms:8-Methoxy-1,2,3,4-tetrahydroisoquinoline;8-Methoxy-1,2,3,4-tetrahydro-isoquinoline;

Chemical Property of 8-methoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 38-39℃
• Refractive Index: 1.532
• Boiling Point: 293.923 °C at 760 mmHg
• PKA: 9.57±0.20(Predicted)
• Flash Point: 113.001 °C
• PSA: 21.26000
• Density: 1.044 g/cm³
• LogP: 1.66970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

8-Methoxy-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 23 articles about 8-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

8-methoxy-3,4-dihydroisoquinolin-1(2H)-one (74904-29-3) → 8-methoxy-1,2,3,4-tetrahydroisoquinoline (34146-68-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00395a006

Reference yield: 90.0%

2-formyl-1,2,3,4-tetrahydro-8-methoxyisoquinoline (29969-40-2) → 8-methoxy-1,2,3,4-tetrahydroisoquinoline (34146-68-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 15h; Heating;

DOI:10.1248/cpb.46.918

Reference yield: 35.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(3-methoxyphenyl)-1-ethanamine (2039-67-0) → 6-methoxy-1,2,3,4-tetrahydro-isoquinoline (42923-77-3) + 8-methoxy-1,2,3,4-tetrahydroisoquinoline (34146-68-4)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 24h; pH=0.4;

DOI:10.1016/j.bmc.2008.05.006

upstream raw materials:

8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

2-formyl-1,2,3,4-tetrahydro-8-methoxyisoquinoline

N-(methoxycarbonyl)-2-(3'-methoxyphenyl)ethylamine

2-(3-methoxyphenyl)-1-ethanamine

Downstream raw materials:

8-Methoxy-2-methyl-1,2,3,4-tetrahydroisochinolin

5-(3,4-Dimethoxybenzylamino)-2-(2-furyl)-8-(8-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ylmethyl)[1,2,4]triazolo[1,5-c]pyrimidine

1-<4-(benzyloxy)benzyl>-8-methoxy-1,2,3,4-tetrahydroisoquinoline

1-(3,4-dimethoxybenzyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline

Refernces

• 1、 -. "A class of GPR40 agonist compounds with amide structure, and uses thereof". Paragraph 0166; 0167; 0172. . Retrieved 2019/05/02.
• 2、 -. "Tyrosine Kinase Inhibitor And Uses Thereof". Paragraph 0886-0887. . Retrieved 2017/05/15.