4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE

Base Information Edit

Chemical Name:4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE
CAS No.:236406-14-7
Molecular Formula:C19H28 N2 O4
Molecular Weight:348.442
Hs Code.:2933399090
Mol file:236406-14-7.mol

Synonyms:1,1-Dimethylethyl4-methyl-4-[[[(phenylmethyl)oxy]carbonyl]amino]-1-piperidinecarboxylate

Suppliers and Price of 4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-BOC-4-(Cbz-amino)-4-methylpiperidine
100mg
$ 65.00

TRC
1-BOC-4-(Cbz-amino)-4-methylpiperidine
250mg
$ 140.00

Crysdot
tert-Butyl4-(((benzyloxy)carbonyl)amino)-4-methylpiperidine-1-carboxylate 95+%
5g
$ 508.00

Chemenu
tert-butyl4-(((benzyloxy)carbonyl)amino)-4-methylpiperidine-1-carboxylate 95%
5g
$ 480.00

AK Scientific
tert-Butyl4-(((benzyloxy)carbonyl)amino)-4-methylpiperidine-1-carboxylate
1g
$ 131.00

Total 6 raw suppliers

Chemical Property of 4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE Edit

Chemical Property:

Vapor Pressure:4.15E-09mmHg at 25°C
Refractive Index:1.542
Boiling Point:472.8°Cat760mmHg
PKA:12.43±0.20(Predicted)
Flash Point:239.7°C
PSA：71.36000
Density:1.14g/cm³
LogP:3.84470

Purity/Quality:

96% ^*data from raw suppliers

1-BOC-4-(Cbz-amino)-4-methylpiperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE

There total 8 articles about 4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 189321-63-9
1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 236406-14-7
1,1-dimethylethyl 4-methyl-4-({[(phenylmethyl)oxy]carbonyl}amino)-1-piperidinecarboxylate

Guidance literature:: 1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 90 ℃; for 2h;

benzyl alcohol; In toluene; at 90 ℃; for 18h;

Reference yield: 70.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 343788-69-2
4-amino-4-methyl-piperidine-1-carboxylic acid tert-butyl ester

: 236406-14-7
1,1-dimethylethyl 4-methyl-4-({[(phenylmethyl)oxy]carbonyl}amino)-1-piperidinecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In ethanol; water; at 20 ℃; for 3h;

Reference yield:

: 124443-68-1
1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

: 236406-14-7
1,1-dimethylethyl 4-methyl-4-({[(phenylmethyl)oxy]carbonyl}amino)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 45 °C

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 - 80 °C / Inert atmosphere

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; water; toluene;