1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) 4-methyl ester

Base Information

• Chemical Name: 1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) 4-methyl ester
• CAS No.: 724790-59-4
• Molecular Formula: C₁₃H₂₃NO₄
• Molecular Weight: 257.33
• Hs Code.: 2933399090
• Mol file: 724790-59-4.mol

Synonyms:4-(Methoxycarbonyl)-4-methylpiperidine-1-carboxylicacid tert-butyl ester;

Chemical Property of 1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) 4-methyl ester

Chemical Property:

• Refractive Index: 1.468
• Boiling Point: 313.2 °C at 760 mmHg
• PKA: -2.26±0.40(Predicted)
• Flash Point: 143.2 °C
• PSA: 66.84000
• Density: 1.068g/cm³
• LogP: 2.55920
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-tert-Butyl4-Methyl4-Methylpiperidine-1,4-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) 4-methyl ester

There total 6 articles about 1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) + methyl iodide (74-88-4) → 4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester (724790-59-4)

Guidance literature:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; toluene; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1002/chem.202001123

Reference yield:

methyl iodide (74-88-4) → 4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester (724790-59-4)

Guidance literature:

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 3.5h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) + methyl iodide (74-88-4) → 4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester (724790-59-4)

Guidance literature:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 - 0 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; cyclohexane; at 20 ℃; for 18h;

upstream raw materials:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

methyl iodide

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

isonipecotic acid

Downstream raw materials:

4-methyl-piperidine-4-carboxylic acid methyl ester

1,1-dimethylethyl 4-methyl-4-({[(phenylmethyl)oxy]carbonyl}amino)-1-piperidinecarboxylate

(4-methyl-piperidin-4-yl)-carbamic acid benzyl ester

ethyl 2-(4-(((benzyloxy)carbonyl)amino)-4-methylpiperidin-1-yl)acetate

Refernces

• 1、 -. "2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF". Paragraph 0172; 0173; 0174; 0175. . Retrieved 2021/04/16.
• 2、 -. "N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE". Page/Page column 96. . Retrieved 2018/04/27.