METHYL-(2-P-TOLYL-ETHYL)-AMINE

Base Information

• Chemical Name: METHYL-(2-P-TOLYL-ETHYL)-AMINE
• CAS No.: 229621-74-3
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• Hs Code.: 2921499090
• Mol file: 229621-74-3.mol

Synonyms:Phenethylamine,N,p-dimethyl- (4CI);Methyl[2-(p-Tolyl)ethyl]amine;

Chemical Property of METHYL-(2-P-TOLYL-ETHYL)-AMINE

Chemical Property:

• Vapor Pressure: 0.09mmHg at 25°C
• Refractive Index: 1.508
• Boiling Point: 224.6 °C at 760 mmHg
• PKA: 10.45±0.10(Predicted)
• Flash Point: 95.304 °C
• PSA: 12.03000
• Density: 0.911 g/cm³
• LogP: 2.14780

Purity/Quality:

98%min ^*data from raw suppliers

Methyl-(2-p-tolyl-ethyl)-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL-(2-P-TOLYL-ETHYL)-AMINE

There total 11 articles about METHYL-(2-P-TOLYL-ETHYL)-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C15H23NO2 (1427565-74-9) → N-methyl-2-(p-tolyl)ethan-1-amine (229621-74-3)

Guidance literature:

With hydrogenchloride; water; In methanol; at 0 - 20 ℃;

DOI:10.1021/ol400393j

Reference yield: 87.0%

methyl [2-(4-methylphenyl)ethyl]carbamate (1380403-84-8) → N-methyl-2-(p-tolyl)ethan-1-amine (229621-74-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1021/acs.jmedchem.0c01441

Reference yield:

2-(p-tolyl)ethylamine (3261-62-9) → N-methyl-2-(p-tolyl)ethan-1-amine (229621-74-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0 - 20 °C

1.2: 1 h

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 - 20 °C

2.2: 5 h / 0 - 20 °C

3.1: water; hydrogenchloride / methanol / 0 - 20 °C

With hydrogenchloride; water; sodium hydride; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/ol400393j

upstream raw materials:

2-(4-methylphenyl)ethyl bromide

methylamine

4-methylphenylmagnesium iodide

para-methylphenylmagnesium bromide

Downstream raw materials:

N-[2-(4-methyl-cyclohexa-1,4-dienyl)ethyl]methylamine

2-cyano-2-diazo-N-methyl-N-(4-methylphenethyl)acetamide

2-cyano-N-methyl-N-(4-methylphenethyl)acetamide

Refernces

• 1、 Zhong, Dayou,Wu, Lin-Yang,Wang, Xing-Zhen,Liu, Wen-Bo. "Iron-Catalyzed Intramolecular C—H Amidation of N-Benzoyloxyureas". supporting information. p. 855 - 858. Retrieved 2021/02/16.
• 2、 -. "INHIBITORS OF N-ACYLPHOSPHATIDYLETHANOLAMINE PHOSPHOLIPASE D (NAPE-PLD)". . . Retrieved 2019/12/15.