Ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Base Information

• Chemical Name: Ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate
• CAS No.: 94687-10-2
• Molecular Formula: C₂₀H₂₄O₇
• Molecular Weight: 376.406
• Mol file: 94687-10-2.mol

Synonyms:ethyl-3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Chemical Property of Ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

There total 10 articles about Ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.9%

ethyl 2-(2-methoxyphenoxy)acetate (13078-21-2) + 3,4-dimethoxy-benzaldehyde (120-14-9) → ethyl-3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate (94687-10-2)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

DOI:10.1039/c8gc01886c

Reference yield:

2-methoxy-phenol (90-05-1) → ethyl-3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate (94687-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile

2.1: lithium diisopropyl amide / tetrahydrofuran

2.2: -78 - 20 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ja401793n

Reference yield:

(3,4-dimethoxyphenyl)methanol (93-03-8) → ethyl-3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate (94687-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; oxygen; nitric acid; hydrogenchloride / water; acetonitrile / 24 h / 45 °C / High pressure; Sealed tube

2.1: lithium diisopropyl amide / tetrahydrofuran

2.2: -78 - 20 °C

With hydrogenchloride; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; oxygen; nitric acid; lithium diisopropyl amide; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/ja401793n

upstream raw materials:

2-methoxy-phenol

ethyl 2-(2-methoxyphenoxy)acetate

3,4-dimethoxy-benzaldehyde

(3,4-dimethoxyphenyl)methanol

Downstream raw materials:

1-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propan-1-one

2-(2-methoxyphenoxy)-1-(3,4-dimethoxyphenyl)-1-oxo-2-propene

Veratric acid

erythro-1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol

Refernces

• 1、 Altmann, Lisa-Marie,Heinrich, Markus R.,Hofmann, Dagmar,Hofmann, Laura Elena,Prusko, Lea. "Sequential Cleavage of Lignin Systems by Nitrogen Monoxide and Hydrazine". . . Retrieved 2020/03/27.
• 2、 -. "CATALYTIC DEPOLYMERIZATION OF LIGNIN TO HIGH VALUE HYDROCARBONS". . . Retrieved 2021/01/23.