ethyl 2-hydroxy-2-mesitylacetate

Base Information

• Chemical Name: ethyl 2-hydroxy-2-mesitylacetate
• CAS No.: 66150-50-3
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 66150-50-3.mol

Synonyms:ethyl 2-hydroxy-2-mesitylacetate

Chemical Property of ethyl 2-hydroxy-2-mesitylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-hydroxy-2-mesitylacetate

There total 7 articles about ethyl 2-hydroxy-2-mesitylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

glyoxylic acid ethyl ester (924-44-7) + 1,3,5-trimethyl-benzene (108-67-8) → ethyl 2-hydroxy-2-mesitylacetate (66150-50-3)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1055/s-0028-1083154

Reference yield:

2,4,6-trimethylmandelic acid (20797-56-2) → ethyl 2-hydroxy-2-mesitylacetate (66150-50-3)

Guidance literature:

With hydrogenchloride; ethanol;

DOI:10.1021/ja01871a072

Reference yield:

mesitylglyoxal (22185-97-3) → ethyl 2-hydroxy-2-mesitylacetate (66150-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminium isopropylate

2: aq. NaOH solution

3: ethanol; aqueous hydrochloric acid

With hydrogenchloride; sodium hydroxide; ethanol; aluminum isopropoxide;

DOI:10.1021/ja01871a072

upstream raw materials:

2,4,6-trimethylmandelic acid

oxalic acid diethyl ester

2-mesitylmagnesium bromide

mesitylglyoxal

Downstream raw materials:

ethyl 2-(2,4,6-trimethylphenyl)-2-oxoacetate

2,4,6-trimethylmandelic acid

Refernces

• 1、 Kwiatkowski, Jacek,Majer, Jakub,Kwiatkowski, Piotr,Jurczak, Janusz. "Simple and efficient synthesis of racemic substituted mandelic acid esters from nonactivated arenes and ethyl glyoxylate". experimental part. p. 3237 - 3244. Retrieved 2009/05/26.