(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester

Base Information

• Chemical Name: (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester
• CAS No.: 1610691-89-8
• Molecular Formula: C₁₆H₂₃ClN₂O₅
• Molecular Weight: 358.822
• Mol file: 1610691-89-8.mol

Synonyms:(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester

Chemical Property of (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester

There total 4 articles about (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(R)-N-(2-chloroacetyl)-2-chlorophenylalanine methyl ester (1610691-84-3) + 2,2-dimethoxyethylamine (22483-09-6) → (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester (1610691-89-8)

Guidance literature:

With sodium iodide; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2014.04.045

Reference yield:

(R)-2-((tert-butoxycarbonyl)amino)-3-(2-chlorophenyl)propanoic acid (114873-02-8,80102-23-4,1407973-04-9) → (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester (1610691-89-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: hydrogenchloride / ethyl acetate / 3 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4: sodium iodide / dichloromethane / 48 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; sodium iodide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2014.04.045

Reference yield:

(R)-2-chlorophenylalanine methyl ester hydrochloride (457654-72-7) → (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester (1610691-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: sodium iodide / dichloromethane / 48 h / 20 °C

With triethylamine; sodium iodide; In dichloromethane;

DOI:10.1016/j.tet.2014.04.045

upstream raw materials:

C₁₅H₂₀ClNO₄

(R)-2-((tert-butoxycarbonyl)amino)-3-(2-chlorophenyl)propanoic acid

(R)-2-chlorophenylalanine methyl ester hydrochloride

(R)-N-(2-chloroacetyl)-2-chlorophenylalanine methyl ester

Refernces