4-Thiazolecarboxylic acid, 2-(hydroxymethyl)- (9CI)

Base Information

• Chemical Name: 4-Thiazolecarboxylic acid, 2-(hydroxymethyl)- (9CI)
• CAS No.: 221322-09-4
• Molecular Formula: C5H5NO3S
• Molecular Weight: 159.166
• Hs Code.: 2934100090
• Mol file: 221322-09-4.mol

Synonyms:2-(Hydroxymethyl)thiazole-4-carboxylicacid;

Chemical Property of 4-Thiazolecarboxylic acid, 2-(hydroxymethyl)- (9CI)

Chemical Property:

• Vapor Pressure: 2.37E-06mmHg at 25°C
• Refractive Index: 1.654
• Boiling Point: 376.9 °C at 760 mmHg
• Flash Point: 181.7 °C
• PSA: 98.66000
• Density: 1.616 g/cm³
• LogP: 0.33360
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(Hydroxymethyl)thiazole-4-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarboxylic acid, 2-(hydroxymethyl)- (9CI)

There total 1 articles about 4-Thiazolecarboxylic acid, 2-(hydroxymethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-methylthiazole-4-carboxylate (6436-59-5) → 2-(hydroxymethyl)-1,3-thiazole-4-carboxylic acid (221322-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: selenium(IV) oxide; acetic acid / Inert atmosphere

2: sodium tetrahydroborate / Inert atmosphere

3: lithium hydroxide / Inert atmosphere

With selenium(IV) oxide; sodium tetrahydroborate; acetic acid; lithium hydroxide;

DOI:10.1126/science.aax2685

Reference yield:

tert-butyl 4-(3-(3'-(3-((1s,4s)-4-aminocyclohexylcarbamoyl)-5-fluoropyridin-2-yloxy)biphenyl-4-yl)propyl)piperazine-1-carboxylate + 2-(hydroxymethyl)-1,3-thiazole-4-carboxylic acid (221322-09-4) → C41H49FN6O6S

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

N-((1s,4s)-4-aminocyclohexyl)-2-(4'-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)biphenyl-3-yloxy)-5-fluoronicotinamide + 2-(hydroxymethyl)-1,3-thiazole-4-carboxylic acid (221322-09-4) → N-((1s,4s)-4-(2-(4'-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)biphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-2-(hydroxymethyl)thiazole-4-carboxamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

ethyl 2-methylthiazole-4-carboxylate

Downstream raw materials:

2-(chloromethyl)-N-[6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide

2-(chloromethyl)-N-{1-(phenylsulfonyl)-6-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide

2-(chloromethyl)-N-[6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide

N-((1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)biphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-2-(hydroxymethyl)thiazole-4-carboxamide trifluoroacetic acid salt

Refernces