2-Ethyl-4'-Methoxy-3-(p-Methoxyphenyl)-valerophenone

Base Information

• Chemical Name: 2-Ethyl-4'-Methoxy-3-(p-Methoxyphenyl)-valerophenone
• CAS No.: 74063-46-0
• Molecular Formula: C₂₁H₂₆O₃
• Molecular Weight: 326.436
• Mol file: 74063-46-0.mol

Synonyms:2-ethyl-1,3-bis-(4-methoxy-phenyl)-pentan-1-one

Chemical Property of 2-Ethyl-4'-Methoxy-3-(p-Methoxyphenyl)-valerophenone

Chemical Property:

• Boiling Point: 459.8±35.0 °C(Predicted)
• Density: 1.041±0.06 g/cm3(Predicted)
• Solubility.: Ether, Ethyl Acetate

Purity/Quality:

98% ^*data from raw suppliers

3-Ethyl-2,4-bis(p-methoxyphenyl)-1-pentanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Benzestrol (B203550) derivative with estrogenic activity.

Technology Process of 2-Ethyl-4'-Methoxy-3-(p-Methoxyphenyl)-valerophenone

There total 3 articles about 2-Ethyl-4'-Methoxy-3-(p-Methoxyphenyl)-valerophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylmagnesium bromide (925-90-6) → 2-ethyl-1,3-bis-(4-methoxy-phenyl)-pentan-1-one (74063-46-0)

Guidance literature:

With diethyl ether; at -10 ℃; optically inactive stereoisomer(ic) of mp: 82 degree;

DOI:10.1021/ja01225a019

Reference yield:

ethylmagnesium bromide (925-90-6) → 2-ethyl-1,3-bis-(4-methoxy-phenyl)-pentan-1-one (74063-46-0)

Guidance literature:

With diethyl ether; at -10 ℃; optically inactive liquid substance;

DOI:10.1021/ja01225a019

Reference yield:

methoxybenzene (100-66-3) → 2-ethyl-1,3-bis-(4-methoxy-phenyl)-pentan-1-one (74063-46-0)

Guidance literature:

With aluminium trichloride; 1,2-dichloro-ethane;

DOI:10.1021/ja01160a017

upstream raw materials:

methoxybenzene

ethylmagnesium bromide

Downstream raw materials:

3-(4-methoxy-benzyl)-4-(4-methoxy-phenyl)-hexane