3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine

Base Information

• Chemical Name: 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine
• CAS No.: 33050-38-3
• Molecular Formula: C5H2 Cl2 N4
• Molecular Weight: 189.004
• Hs Code.: 2933998090
• European Community (EC) Number: 806-625-2
• DSSTox Substance ID: DTXSID90363257
• Wikidata: Q72468421
• ChEMBL ID: CHEMBL1406965
• Mol file: 33050-38-3.mol

Synonyms:33050-38-3;3,6-dichloro-[1,2,4]triazolo[4,3-b]pyridazine;3,6-dichloro[1,2,4]triazolo[4,3-b]pyridazine;1,2,4-Triazolo[4,3-b]pyridazine, 3,6-dichloro-;MLS000694534;SCHEMBL612506;CHEMBL1406965;DTXSID90363257;HMS2630D10;AMY31817;MFCD00139673;AKOS005069566;SMR000333208;CS-0081021;FT-0680056;3,6-dichloro-1,2,4-triazolo[4,3-b]pyridazine;12D-022;3.6-Dichloro(1.2.4)triazolo1-4.3-bipyridazine;A875446;J-511389

Chemical Property of 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine

Chemical Property:

• Melting Point: 140-143°C
• Refractive Index: 1.807
• PSA: 43.08000
• Density: 1.90
• LogP: 1.43110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 187.9656515
• Heavy Atom Count: 11
• Complexity: 155

Purity/Quality:

99.3% ^*data from raw suppliers

3,6-Dichloro-[1,2,4]triazolo[4,3-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NN2C1=NN=C2Cl)Cl

Technology Process of 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine

There total 8 articles about 3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one (33050-32-7) → 3,6-dichloro-1,2,4-triazolo<4,3-b>pyridazine (33050-38-3)

Guidance literature:

With trichlorophosphate; for 20h; Reflux;

Reference yield: 48.0%

6-chloro[1,2,4]triazolo[4,3-b]pyridazine (28593-24-0) → 3,6-dichloro-1,2,4-triazolo<4,3-b>pyridazine (33050-38-3)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 3h; Heating;

Reference yield: 42.0%

3-Chloro-6-hydrazinopyridazine (17284-97-8) + chloroformic acid ethyl ester (541-41-3) → 3,6-dichloro-1,2,4-triazolo<4,3-b>pyridazine (33050-38-3)

Guidance literature:

In ethanol; for 1h;

upstream raw materials:

6-chloro[1,2,4]triazolo[4,3-b]pyridazine

3-Chloro-6-hydrazinopyridazine

chloroformic acid ethyl ester

6-chloro-3-methyl-1,2,4-triazolo<4,3-b>pyridazine

Downstream raw materials:

6-(4'-fluorobiphenyl-2-yloxy)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine

6-(2',4'-difluorobiphenyl-2-yloxy)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine

5-(2-(3-chloro-[1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)-4-(trifluoromethyl)phenyl)-N,N-dimethylpyridin-2-amine

3-chloro-6-(4-acetamidobiphenyl-2-yloxy)-[1,2,4]triazolo[4,3-b]pyridazine

Refernces

• 1、 -. "DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS". Page/Page column 43. . Retrieved 2013/04/13.