p-aminophenyl isocyanide

Base Information

• Chemical Name: p-aminophenyl isocyanide
• CAS No.: 69236-29-9
• Molecular Formula: C₇H₆N₂
• Molecular Weight: 118.138
• Mol file: 69236-29-9.mol

Synonyms:p-aminophenyl isocyanide

Chemical Property of p-aminophenyl isocyanide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-aminophenyl isocyanide

There total 3 articles about p-aminophenyl isocyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

sodium chlorodifluoroacetate (1895-39-2) + 1,4-phenylenediamine (106-50-3) → p-aminophenyl isocyanide (69236-29-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.0c03472

Reference yield: 76.0%

p-nitrophenyl isocyanide (1984-23-2) → p-aminophenyl isocyanide (69236-29-9)

Guidance literature:

With Li*4.5 THF; In methanol; at 20 - 25 ℃; for 72h;

Reference yield: 45.0%

chloroform (67-66-3,8013-54-5) + 1,4-phenylenediamine (106-50-3) → p-aminophenyl isocyanide (69236-29-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 2.5h; Heating;

DOI:10.1002/ejic.200300272

upstream raw materials:

chloroform

1,4-phenylenediamine

p-nitrophenyl isocyanide

sodium chlorodifluoroacetate

Downstream raw materials:

1,4-phenylenediisocyanide

Refernces

• 1、 Si, Yi-Xin,Zhu, Peng-Fei,Zhang, Song-Lin. "Synthesis of isocyanides by reacting primary amines with difluorocarbene". supporting information. p. 9086 - 9090. Retrieved 2020/11/30.
• 2、 Eckert, Heiner. "Selektive Reduktion der Nitro- zur Aminogruppe durch das Cobalt(I)-phthalocyanin-Anion; Synthese von N-Heterocyclen und Alkaloiden". . p. 216 - 218. Retrieved 2007/10/02.