ETHYL 2?FLUOROCINNAMATE

Base Information

• Chemical Name: ETHYL 2?FLUOROCINNAMATE
• CAS No.: 348-13-0
• Molecular Formula: C11H11 F O2
• Molecular Weight: 194.206
• Hs Code.: 2916399090
• Mol file: 348-13-0.mol

Synonyms:Cinnamicacid, 2-fluoro-, ethyl ester (8CI); 3-(2-Fluorophenyl)acrylic acid ethyl ester;Ethyl 2-fluorocinnamate

Chemical Property of ETHYL 2?FLUOROCINNAMATE

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 269.008°C at 760 mmHg
• Flash Point: 112.99°C
• PSA: 26.30000
• Density: 1.135g/cm³
• LogP: 2.40200

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-fluorocinnamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2?FLUOROCINNAMATE

There total 8 articles about ETHYL 2?FLUOROCINNAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ ethyl 3-(2-fluorophenyl)propenoate (348-13-0)

Guidance literature:

Reference yield: 97.0%

1-Fluoro-2-iodobenzene (348-52-7) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-(2-fluorophenyl)propenoate (348-13-0)

Guidance literature:

With C₂₈H₄₀Br₄N₄Pd₂; triethylamine; In N,N-dimethyl-formamide; at 90 ℃; for 4h;

DOI:10.1039/c4ra06284a

Reference yield: 95.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 2-Fluorobenzaldehyde (446-52-6) → ethyl 3-(2-fluorophenyl)propenoate (348-13-0)

Guidance literature:

With N,N,N',N'-tetramethylguanidine; In chloroform; at 50 ℃; for 4h;

upstream raw materials:

ethanol

2-fluorocinnamic acid

2-Fluorobenzaldehyde

ethyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

ethyl 3-(2-fluorophenyl)-4-nitrobutanoate

3-(2-fluorophenoxy)propyl chloride

2-fluorocinnamic acid

(E)-3-(2-fluorophenyl)-prop-2-en-1-ol

Refernces

• 1、 -. "NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME". Paragraph 0394-0395. . Retrieved 2021/07/24.
• 2、 Ichikawa, Saki,Buchwald, Stephen L.. "Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination". supporting information. p. 8736 - 8739. Retrieved 2019/11/03.