Technology Process of (R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (S)-mandelate
There total 5 articles about (R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (S)-mandelate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7-Methoxy-1,2,3,4-tetrahydro-(2R)-2-naphthaleneamine hydrochloride;
With
sodium hydroxide;
In
water; ethyl acetate;
(S)-Mandelic acid;
In
methanol; water; isopropyl alcohol; toluene;
Reflux;
Resolution of racemate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 0.25 h / Inert atmosphere
1.2: 15 h / 20 °C / Inert atmosphere
2.1: 20 % Pd(OH)2/C; hydrogen; acetic acid / ethanol / 24.08 h / 20 °C
3.1: sodium hydroxide / water; ethyl acetate
4.1: methanol; water; isopropyl alcohol; toluene / 0.5 h / Reflux
With
20 % Pd(OH)2/C; hydrogen; acetic acid; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1021/jm101479y
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / water; ethyl acetate
2: methanol; water; isopropyl alcohol; toluene / 0.5 h / Reflux
With
sodium hydroxide;
In
methanol; water; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1021/jm101479y