2-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

Base Information

• Chemical Name: 2-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone
• CAS No.: 343-04-4
• Molecular Formula: C9H8 Br F O2
• Molecular Weight: 247.064
• Hs Code.: 2914700090
• European Community (EC) Number: 803-519-8
• Mol file: 343-04-4.mol

Synonyms:2-bromo-1-(5-fluoro-2-methoxyphenyl)ethanone;343-04-4;a-Bromo-5'-fluoro-2'-methoxyacetophenone;2-bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one;2-bromo-1-(5-fluoro-2-methoxy-phenyl)-ethanone;2-Bromo-5'-fluoro-2'-methoxyacetophenone;2-Bromo-1-(5-fluoro-2-methoxy-phenyl)ethanone;MFCD03425169;SCHEMBL2097494;BHVKAQAGKAZQDP-UHFFFAOYSA-N;AKOS001359334;FS-4594;CS-0093673;EN300-34779;2-Bromo-5'-fluoro-2'-methoxyacetophenone, 97%;A900690;Z235336585

Chemical Property of 2-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

Chemical Property:

• Melting Point: 75-80°C
• PSA: 26.30000
• LogP: 2.41190
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 245.96917
• Heavy Atom Count: 13
• Complexity: 187

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)F)C(=O)CBr

Technology Process of 2-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

There total 3 articles about 2-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-fluoro-4-methoxybenzene (459-60-9) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one (343-04-4)

Guidance literature:

With aluminum (III) chloride; In carbon disulfide; at 20 ℃; for 12h; Temperature; Solvent; Reagent/catalyst;

Reference yield: 48.6%

1-(5-fluoro-2-methoxyphenyl)ethanone (445-82-9) → 2-bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one (343-04-4)

Guidance literature:

With copper(ll) bromide; In chloroform; for 4h; Reflux;

Reference yield:

→ 2-bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one (343-04-4)

Guidance literature:

/BRN= 3251326/;

DOI:10.1021/jo01375a009

upstream raw materials:

1-(5-fluoro-2-methoxyphenyl)ethanone

1-fluoro-4-methoxybenzene

2-Bromoacetyl bromide

Downstream raw materials:

2-(5-fluoro-2-methoxy-phenyl)-7-methyl-indolizine

2-(5-fluoro-2-methoxy-phenyl)-quinoxaline

C₁₀H₈FNO₂

2-(2-acetylimino-thiazolidin-3-yl)-1-(5-fluoro-2-methoxy-phenyl)-ethanol

Refernces

• 1、 -. "ROR-GAMMA INHIBITORS". Page/Page column 269. . Retrieved 2019/04/26.
• 2、 Lee, Sunkyung,Kim, Taemi,Lee, Byung Ho,Yoo, Sung-eun,Lee, Kyunghee,Yi, Kyu Yang. "3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors". . p. 1291 - 1295. Retrieved 2008/02/02.