445-82-9

Basic information

• Product Name: 5-FLUORO-2-METHOXYACETOPHENONE
• Synonyms: 1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE;5'-FLUORO-2'-METHOXYACETOPHENONE;5-FLUORO-2-METHOXYACETOPHENONE;Albb-004400;1-(5-Fluoro-2-methoxyphenyl)ethanon
• CAS NO: 445-82-9
• Molecular Formula: C₉H₉FO₂
• Molecular Weight: 168.16
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Fluorine series
• Mol File: 445-82-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 23 °C
• Boiling Point: 246.8 °C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.1880
• Refractive Index: 1.5180
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-FLUORO-2-METHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-METHOXYACETOPHENONE(445-82-9)
• EPA Substance Registry System: 5-FLUORO-2-METHOXYACETOPHENONE(445-82-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 445-82-9(Hazardous Substances Data)

Usage

General Description

5-FLUORO-2-METHOXYACETOPHENONE is a synthetic chemical compound that belongs to the class of acetophenone derivatives. It is characterized by the presence of a fluorine atom at the fifth position and a methoxy group at the second position of the acetophenone molecule. 5-FLUORO-2-METHOXYACETOPHENONE is used in organic synthesis and pharmaceutical research as an intermediate in the production of various drugs and other organic compounds. It has potential applications in the development of new drugs with therapeutic properties. Additionally, 5-FLUORO-2-METHOXYACETOPHENONE can also be used as a building block for the synthesis of complex organic molecules in the field of medicinal chemistry and drug discovery.

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 75-36-5 acetyl chloride 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 77-78-1 dimethyl sulfate 
• 579-74-8 2-Methoxyacetophenone 
• 74-88-4 methyl iodide 
• 75-16-1 methylmagnesium bromide 
• 189628-38-4 5-fluoro-2-methoxybenzonitrile 

Downstream Products

• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 394-04-7 5-fluoro-2-methoxybenzoic acid 
• 446-77-5 2-(5-fluoro-2-methoxy-phenyl)-quinoline-4-carboxylic acid 
• 71313-97-8 2-(5-fluoro-2-methoxyphenyl)propan-2-ol 
• 715-89-9 2-Amino-4-<5-fluor-2-methoxyphenyl>-thiazol 
• 62433-46-9 [4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-(4-methoxy-phenyl)-amine 
• 62433-45-8 [4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-(2-methoxy-phenyl)-amine 
• 62433-43-6 (4-chloro-phenyl)-[4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-amine 
• 887591-34-6 C₁₀H₈FNO₂ 
• 934340-27-9 C₁₃H₁₂FNO₄ 
• 179111-05-8 3-bromo-6-fluoro-4H-chromen-4-one 
• 1354928-53-2 C₁₇H₁₁FO₄ 
• 1346818-41-4 (R)-1-(5-fluoro-2-methoxyphenyl)ethanol 

Relevant articles and documents

Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis

Two new series of ring-opened analogues of cromakalim bearing sulfonylurea moieties (series A: with N-unmethylated sulfonylureas, series B: with N-methylated sulfonylureas) were synthesized and tested as relaxants of vascular and respiratory smooth muscle

Chromenones as potent bradykinin B1 antagonists

A series of fused 6,6-bicyclic chromenones was investigated for activity against the bradykinin B1 receptor. SAR studies based on a pharmacophore model revealed compounds with high affinity for both human and rabbit B1. These compounds demonstrated favorable pharmacokinetic properties and 5-chlorochromenone 15 was efficacious in a carrageenan-induced mechanical hyperalgesia model for chronic pain.

Solvent directing immediate fluorination of aromatic ketones using 1- fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)

Reactions of aryl alkyl ketones with 1-fluoro-4-hydroxy1,4- diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Accufluor(TM) NFTh) in methanol result in selective and almost quantitative formation of the corresponding α-fluoroketones, while in acetonitrile exclusive fluorofunctionalisation of the activated aromatic ring take place.