934340-27-9

Basic information

• Product Name: C₁₃H₁₂FNO₄
• CAS NO: 934340-27-9
• Molecular Weight: 265.241
• Mol File: 934340-27-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₂FNO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₂FNO₄(934340-27-9)
• EPA Substance Registry System: C₁₃H₁₂FNO₄(934340-27-9)

Safety Data

• Hazardous Substances Data: 934340-27-9(Hazardous Substances Data)

Upstream product

• 343-04-4 2-bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one 
• 445-82-9 1-(5-fluoro-2-methoxyphenyl)ethanone 
• 887591-34-6 C₁₀H₈FNO₂ 

Relevant articles and documents

3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors

The C-3 substituents effect on NHE-1 inhibitory activity of (5-arylfuran-2-ylcarbonyl)guanidines, previously identified as potent NHE-1 inhibitors, was investigated. The introduction of amine or alkyl groups at the 3-position of the furan ring, next to the acylguanidine moiety, remarkably improves NHE-1 inhibitory potency. Especially the important finding is that 5-(2,5-dichloro)phenyl and 5-(2-methoxy-5-chloro)phenyl derivatives exhibit high NHE-1 inhibitory activities (IC50 0.02 μM) that match those of 3-unsubstituted derivatives.