179111-05-8

Basic information

• Product Name: 3-BROMO-6-FLUOROCHROMONE
• Synonyms: 3-BROMO-6-FLUORO-4H-1-BENZOPYRAN-4-ONE;3-BROMO-6-FLUORO-4H-CHROMEN-4-ONE;3-BROMO-6-FLUOROCHROMONE
• CAS NO: 179111-05-8
• Molecular Formula: C9H4BrFO2
• Molecular Weight: 243.03
• Mol File: 179111-05-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 130-134 °C(lit.)
• Boiling Point: 279.7 °C at 760 mmHg
• Flash Point: 123 °C
• Appearance: /
• Density: 1.818 g/cm³
• Vapor Pressure: 0.00395mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 3-BROMO-6-FLUOROCHROMONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-6-FLUOROCHROMONE(179111-05-8)
• EPA Substance Registry System: 3-BROMO-6-FLUOROCHROMONE(179111-05-8)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 179111-05-8(Hazardous Substances Data)

Usage

General Description

3-BROMO-6-FLUOROCHROMONE is a chemical compound with the molecular formula C9H4BrFO. It is a synthetic, aromatic compound that belongs to the class of chromones. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is known for its potential biological activities and has been studied for its antimicrobial and anti-inflammatory properties. 3-BROMO-6-FLUOROCHROMONE may also have potential applications in the development of new drugs for various medical conditions due to its unique chemical structure and reactivity. However, it is important to handle this chemical with caution, as it may pose health and environmental hazards if not handled properly.

InChI:InChI=1/C9H4BrFO2/c10-7-4-13-8-2-1-5(11)3-6(8)9(7)12/h1-4H

Upstream product

• 189628-38-4 5-fluoro-2-methoxybenzonitrile 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 445-82-9 1-(5-fluoro-2-methoxyphenyl)ethanone 

Relevant articles and documents

Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes

Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by employing the simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for the simple and mild room temperature operation, environmental friendliness as well as broad substrate scope in both C-H bond donor and halogen source components.

Chromenones as potent bradykinin B1 antagonists

A series of fused 6,6-bicyclic chromenones was investigated for activity against the bradykinin B1 receptor. SAR studies based on a pharmacophore model revealed compounds with high affinity for both human and rabbit B1. These compounds demonstrated favorable pharmacokinetic properties and 5-chlorochromenone 15 was efficacious in a carrageenan-induced mechanical hyperalgesia model for chronic pain.