7-FLUORO INDAZOLE

Base Information

• Chemical Name: 7-FLUORO INDAZOLE
• CAS No.: 341-24-2
• Molecular Formula: C7H5 F N2
• Molecular Weight: 136.13
• Hs Code.: 2933990090
• Mol file: 341-24-2.mol

Synonyms:7-FLUORO INDAZOLE;7-Fluoro-1H-indazole;1H-Indazole, 7-fluoro-;7-fluoro-1(2)H-indazole

Chemical Property of 7-FLUORO INDAZOLE

Chemical Property:

• Vapor Pressure: 0.00883mmHg at 25°C
• Melting Point: 120 °C (decomp)
• Refractive Index: 1.658
• Boiling Point: 274.9 °C at 760 mmHg
• PKA: 12.10±0.40(Predicted)
• Flash Point: 120.1 °C
• PSA: 28.68000
• Density: 1.37 g/cm³
• LogP: 1.70200
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Fluoro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-FLUORO INDAZOLE

There total 4 articles about 7-FLUORO INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2,3-difluorobenzaldehyde (2646-91-5) → 7-fluoro-1H-indazole (341-24-2)

Guidance literature:

With hydrazine; at 180 ℃; for 10h;

Reference yield: 41.0%

2,3-difluoroacetophenone (18355-80-1) → 7-fluoro-1H-indazole (341-24-2)

Guidance literature:

With hydrazine hydrate; Reflux;

DOI:10.1016/j.ejmech.2014.09.083

Reference yield:

3-fluorosalicylaldehyde (394-50-3) → 7-fluoro-1H-indazole (341-24-2)

Guidance literature:

With hydrazine hydro-chloride; In ethanol; for 3h; Reflux;

DOI:10.3987/COM-17-13826

upstream raw materials:

2,3-difluorobenzaldehyde

2,3-difluoroacetophenone

3-fluorosalicylaldehyde

Downstream raw materials:

7-fluoro-4-nitro-1H-indazole

7-fluoro-5-nitro-1H-indazole

Refernces

• 1、 -. "HETEROCYCLE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONIST ACTIVITY". Paragraph 0626. . Retrieved 2014/07/22.
• 2、 -. "THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING C-MET AUTOPHOSPHORYLATION INHIBITING POTENCY". Page/Page column 23. . Retrieved 2008/06/13.