4-FLUORO (1H)INDAZOLE

Base Information

• Chemical Name: 4-FLUORO (1H)INDAZOLE
• CAS No.: 341-23-1
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.129
• Hs Code.: 2933990090
• Mol file: 341-23-1.mol

Synonyms:4-Fluoro-1H-indazole;

Chemical Property of 4-FLUORO (1H)INDAZOLE

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Melting Point: 130.0 to 134.0 °C
• Refractive Index: 1.659
• Boiling Point: 274.892 °C at 760 mmHg
• PKA: 13.21±0.40(Predicted)
• Flash Point: 120.051 °C
• PSA: 28.68000
• Density: 1.371 g/cm³
• LogP: 1.70200
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Fluoro-1H-indazole

Technology Process of 4-FLUORO (1H)INDAZOLE

There total 7 articles about 4-FLUORO (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2,6-difluorobenzaldehyde (437-81-0) → 4-fluoro-1H-indazole (341-23-1)

Guidance literature:

With hydrazine; In 1,4-dioxane; at 110 ℃; for 3h;

DOI:10.1021/jo9006656

Reference yield:

2,6-difluoroacetophenone (13670-99-0) → 4-fluoro-1H-indazole (341-23-1)

Guidance literature:

With hydrazine hydrate; Reflux;

DOI:10.1016/j.ejmech.2014.09.083

Reference yield:

3-fluoro-2-methylaniline (443-86-7) → 4-fluoro-1H-indazole (341-23-1)

Guidance literature:

3-fluoro-2-methylaniline; With tetrafluoroboric acid; sodium nitrite; In water; at 0 - 20 ℃;

With 18-crown-6 ether; potassium acetate; In chloroform; at 20 ℃; Further stages.;

DOI:10.1016/j.bmcl.2007.03.024

upstream raw materials:

benzoic acid-(3-fluoro-2-methyl-N-nitroso-anilide)

3-fluoro-2-methylaniline

1-fluoro-2-methyl-3-nitrobenzene

3-nitro-o-tolylamine

Downstream raw materials:

4-fluoro-1-(4-methoxybenzyl)-1H-indazole

4-fluoro-2-(4-methoxybenzyl)-2H-indazole

3-bromo-4-fluoro-1H-indazole

(3-bromo-4-fluoro-1H-indazol-1-yl)(2-chloro-6-(trifluoromethyl)phenyl)methanone

Refernces

• 1、 Slade, David J.,Pelz, Nicholas F.,Bodnar, Wanda,Lampe, John W.,Watson, Paul S.. "Indazoles: Regioselective protection and subsequent amine coupling reactions". supporting information; experimental part. p. 6331 - 6334. Retrieved 2009/12/26.
• 2、 Lukin, Kirill,Hsu, Margaret C.,Fernando, Dilinie,Leanna, M. Robert. "New practical synthesis of indazoles via condensation of o-fluorobenzaldehydes and their O-methyloximes with hydrazine". . p. 8166 - 8172. Retrieved 2007/10/03.