13670-99-0 Usage
Description
1-(2,6-Difluorophenyl)ethan-1-one, also known as 2',6'-Difluoroacetophenone, is a clear, colorless to light yellow liquid with unique chemical properties. It is characterized by the presence of two fluorine atoms at the 2' and 6' positions of the phenyl ring, which imparts specific reactivity and stability to the molecule. 1-(2,6-Difluorophenyl)ethan-1-one is synthesized through a ruthenium-catalyzed phenylation process involving carbon-fluorine bond cleavage, resulting in 2',6'-diphenylacetophenone.
Uses
1. Used in Pharmaceutical Synthesis:
1-(2,6-Difluorophenyl)ethan-1-one is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly 2-amino-4-alkyland 2-amino-4-arylquinazolines. These quinazoline derivatives have potential applications in the treatment of various diseases, including cancer and other proliferative disorders.
2. Used in Chemical Research:
As a versatile synthetic building block, 1-(2,6-Difluorophenyl)ethan-1-one is employed in chemical research for the development of novel compounds with specific properties. Its unique fluorinated structure allows for the exploration of new reaction pathways and the creation of innovative molecules with potential applications in various fields.
3. Used in Material Science:
The compound's chemical properties, including its stability and reactivity, make it a candidate for use in the development of new materials with specific characteristics. These materials could have applications in various industries, such as electronics, coatings, and adhesives, where properties like thermal stability and chemical resistance are desired.
4. Used in the Synthesis of Fluorinated Compounds:
Due to the presence of fluorine atoms, 1-(2,6-Difluorophenyl)ethan-1-one can be utilized in the synthesis of other fluorinated compounds. Fluorinated molecules often exhibit enhanced properties, such as increased stability, reactivity, and bioavailability, making them valuable in various applications, including pharmaceuticals, agrochemicals, and specialty materials.
Check Digit Verification of cas no
The CAS Registry Mumber 13670-99-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,6,7 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13670-99:
(7*1)+(6*3)+(5*6)+(4*7)+(3*0)+(2*9)+(1*9)=110
110 % 10 = 0
So 13670-99-0 is a valid CAS Registry Number.
13670-99-0Relevant articles and documents
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Roe,A.M. et al.
, p. 814 - 819 (1968)
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Redox-driven deracemization of secondary alcohols by sequential ether/O2-mediated oxidation and Ru-catalyzed asymmetric reduction
Yang, Bing,Cui, Peng,Chen, Yongsheng,Liu, Qixing,Zhou, Haifeng
supporting information, (2020/10/14)
The deracemization of benzylic alcohols has been achieved using a redox-driven one-pot two-step process. The racemic alcohols were oxidized by bis(methoxypropyl) ether and oxygen to give the ketone intermediates, followed by an asymmetric transfer hydrogenation with a chiral ruthenium catalyst. This compatible oxidation/reduction process gave the enantiomerically enriched alcohols with up to 95% ee values.
Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases
Martínez-Montero, Lía,Gotor, Vicente,Gotor-Fernández, Vicente,Lavandera, Iván
supporting information, p. 474 - 480 (2017/06/23)
A one-pot/two-step bienzymatic asymmetric amination of secondary alcohols is disclosed. The approach is based on a sequential strategy involving the use of a laccase/TEMPO catalytic system for the oxidation of alcohols into ketone intermediates, and their following transformation into optically enriched amines by using transaminases. Individual optimizations of the oxidation and biotransamination reactions have been carried out, studying later their applicability in a concurrent process. Therefore, 17 racemic (hetero) aromatic sec-alcohols with different substitutions in the aromatic ring have been converted into enantioenriched amines with good to excellent selectivities (90-99% ee) and conversion values (67-99%). The scalability of the process was also demonstrated when two different amine donors were used in the transamination step, such as isopropylamine and cis-2-buten-1,4-diamine. Satisfyingly, both sacrificial amine donors can shift the equilibrium toward the amine formation, leading to the corresponding isolated enantioenriched amines with good to excellent results.
