4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole

Base Information

• Chemical Name: 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole
• CAS No.: 99973-40-7
• Molecular Formula: C₁₁H₉N₃S₂
• Molecular Weight: 247.345
• Mol file: 99973-40-7.mol

Synonyms:4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole

Chemical Property of 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole

There total 5 articles about 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-amino-4-(p-methylphenyl)-1,3-thiazole (2103-91-5) + ammonium thiocyanate (1147550-11-5) → 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole (99973-40-7)

Guidance literature:

With air; alizarine red S-sensitized TiO₂; In tetrahydrofuran; at 25 ℃; for 24h; regioselective reaction; Irradiation; Green chemistry;

DOI:10.1039/c9cy02268f

Reference yield: 93.0%

ammonium thiocyanate + 2-amino-4-(p-methylphenyl)-1,3-thiazole (2103-91-5) → 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole (99973-40-7)

Guidance literature:

With air; Ag/TiO₂ nanotubes; In tetrahydrofuran; at 20 ℃; for 24h; Irradiation; Green chemistry;

DOI:10.1039/c8nj03128b

Reference yield: 80.0%

potassium thioacyanate (333-20-0) + 1-(1-azidovinyl)-4-methyl benzene (89108-49-6) → 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole (99973-40-7)

Guidance literature:

With ferric(III) bromide; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1021/acs.orglett.5b02152

upstream raw materials:

2-amino-4-(p-methylphenyl)-1,3-thiazole

ammonium thiocyanate

potassium thioacyanate

1-(1-azidovinyl)-4-methyl benzene

Refernces

• 1、 Hosseini-Sarvari, Mona,Hosseinpour, Zeinab,Koohgard, Mehdi,Sarvestani, Abdollah Masoudi. "ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light". . p. 1401 - 1407. Retrieved 2020/03/26.
• 2、 -. "4 - substituted -5 - cyano group -2 - amino thiazole compound preparation method". Paragraph 0025; 0057-0060. . Retrieved 2017/05/06.