4-(4-Methylphenyl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-(4-Methylphenyl)-1,3-thiazol-2-amine
• CAS No.: 2103-91-5
• Molecular Formula: C10H10N2S
• Molecular Weight: 190.269
• Hs Code.: 2934100090
• European Community (EC) Number: 626-896-9
• NSC Number: 54436
• DSSTox Substance ID: DTXSID60943328
• Nikkaji Number: J580.611I
• Wikidata: Q82920385
• ChEMBL ID: CHEMBL1716073
• Mol file: 2103-91-5.mol

Synonyms:2103-91-5;4-(4-methylphenyl)-1,3-thiazol-2-amine;2-Amino-4-(p-tolyl)thiazole;4-(p-tolyl)thiazol-2-amine;4-p-Tolyl-thiazol-2-ylamine;4-p-Tolyl thiazol-2-ylamine;4-p-tolylthiazol-2-amine;4-(4-Methylphenyl)-2-thiazolamine;NSC 54436;4-p-Tolylthiazol-2-ylamine;MLS002667687;4-(4-methylphenyl)-1,3-thiazole-2-ylamine;MFCD00170264;2-thiazolamine, 4-(4-methylphenyl)-;NSC54436;thiazol-2-amine, 2;ChemDiv2_001239;Cambridge id 5341867;2-Amino-4(p-toly)thiazole;Oprea1_047888;Oprea1_117699;2-Amino-4(p-tolyl)thiazole;4-(p-Tolyl)-2-thiazolamine;SCHEMBL231094;CHEMBL1716073;BDBM31191;DTXSID60943328;HMS1372I07;HMS3080G04;Thiazole, 2-amino-4-(p-tolyl)-;CCG-44018;NSC-54436;STK070471;2-amino-4-(4-methylphenyl)-thiazol;2-Amino-4-(p-tolyl)thiazole, 96%;AKOS000104242;AKOS002314847;AB04274;MS-6261;UPCMLD0ENAT5678768:001;SMR001557447;2-AMINO-4-(4-METHYLPHENYL)THIAZOLE;4-(4-methylphenyl)-1,3-thiazol-2-ylamine;BB 0218468;CS-0022329;EU-0079653;FT-0611076;4-(4-methylphenyl)-1,3-thiazol-2-yl-amine;EN300-02255;4-(4-methylphenyl)-1,3-thiazol-2(3H)-imine;AE-641/01182058;SR-01000596924;J-013784;SR-01000596924-1;SR-01000596924-2;Z48847560;F0771-2065

Chemical Property of 4-(4-Methylphenyl)-1,3-thiazol-2-amine

Chemical Property:

• Vapor Pressure: 1.19E-05mmHg at 25°C
• Melting Point: 132-136 °C(lit.)
• Refractive Index: 1.642
• Boiling Point: 369.4 °C at 760 mmHg
• PKA: 4.51±0.10(Predicted)
• Flash Point: 177.2 °C
• PSA: 67.15000
• Density: 1.219 g/cm³
• LogP: 3.28190
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 190.05646950
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Methylphenyl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CSC(=N2)N

Technology Process of 4-(4-Methylphenyl)-1,3-thiazol-2-amine

There total 26 articles about 4-(4-Methylphenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiourea (17356-08-0) + 4-(bromoacetyl)toluene (619-41-0) → 2-amino-4-(p-methylphenyl)-1,3-thiazole (2103-91-5)

Guidance literature:

In ethanol; for 1h; Reflux;

Reference yield: 96.0%

thiourea (17356-08-0) + 2-diazo-1-(4-methylphenyl)ethanone (17263-64-8) → 2-amino-4-(p-methylphenyl)-1,3-thiazole (2103-91-5)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 80 ℃; for 2h;

DOI:10.1016/j.tetlet.2008.02.068

Reference yield: 94.0%

thiourea (17356-08-0) + para-methylacetophenone (122-00-9) → 2-amino-4-(p-methylphenyl)-1,3-thiazole (2103-91-5)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 85 ℃; for 4h; Catalytic behavior;

DOI:10.1016/j.molstruc.2019.02.080

upstream raw materials:

thiourea

para-methylacetophenone

4-(bromoacetyl)toluene

1-(4-methylphenyl)-2-(p-tolylsulfonyloxy)ethanone

Downstream raw materials:

4-fluoro-benzenesulfonic acid-(4-p-tolyl-thiazol-2-ylamide)

4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole

4,4'-di-p-tolyl-5,5'-benzylidene-bis-thiazol-2-ylamine

N-acetyl-sulfanilic acid-(4-p-tolyl-thiazol-2-ylamide)

Refernces

• 1、 Kakati, Praachi,Singh, Preeti,Yadav, Priyanka,Awasthi, Satish Kumar. "Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives". . p. 6724 - 6738. Retrieved 2021/04/22.
• 2、 Ujwaldev, Sankuviruthiyil M.,Harry, Nissy Ann,Neetha, Mohan,Anilkumar, Gopinathan. "Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation". supporting information. p. 646 - 653. Retrieved 2020/10/20.