2-(4-Chlorophenyl)ethyl chloride

Base Information

• Chemical Name: 2-(4-Chlorophenyl)ethyl chloride
• CAS No.: 32327-70-1
• Molecular Formula: C8H8 Cl2
• Molecular Weight: 175.058
• Hs Code.: 2903999090
• European Community (EC) Number: 835-838-3
• DSSTox Substance ID: DTXSID10396446
• Nikkaji Number: J1.838.728J
• Wikidata: Q82197167
• Mol file: 32327-70-1.mol

Synonyms:1-chloro-4-(2-chloroethyl)benzene;32327-70-1;2-(4-CHLOROPHENYL)ETHYL CHLORIDE;2-(4-Chlorophenyl)ethylchloride;1-chloro-4-(2-chloro-ethyl)-benzene;Benzene, 1-chloro-4-(2-chloroethyl)-;4-chlorophenethyl chloride;SCHEMBL130660;DTXSID10396446;KMXUKZCMNKLUTF-UHFFFAOYSA-N;AMY14369;MFCD00045294;AKOS009359067;AS-33195;A5803;CS-0186330;FT-0660327;EN300-245889

Chemical Property of 2-(4-Chlorophenyl)ethyl chloride

Chemical Property:

• Vapor Pressure: 0.079mmHg at 25°C
• Melting Point: 172-176oC
• Refractive Index: 1.538
• Boiling Point: 70°C/ .8mm
• Flash Point: 96.2°C
• PSA: 0.00000
• Density: 1.202g/cm³
• LogP: 3.12130
• Storage Temp.: 2-8°C
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 174.0003056
• Heavy Atom Count: 10
• Complexity: 85.3

Purity/Quality:

99.5% ^*data from raw suppliers

2-(4-Chlorophenyl)ethylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CCCl)Cl

Technology Process of 2-(4-Chlorophenyl)ethyl chloride

There total 14 articles about 2-(4-Chlorophenyl)ethyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4-Chlorophenyl)ethanol (1875-88-3) → 1-chloro-4-(2-chloroethyl)benzene (32327-70-1)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2014.02.006

Reference yield: 95.0%

C15H17ClN2O2S (146404-41-3) → 1-chloro-4-(2-chloroethyl)benzene (32327-70-1) + p-toluenesulfonyl chloride (98-59-9)

Guidance literature:

With N-chloro-succinimide; In tetrahydrofuran; for 16h; Ambient temperature; Irradiation;

DOI:10.1016/0040-4039(94)80009-X

Reference yield: 92.0%

Chloroiodomethane (593-71-5) + 4-chlorobenzaldehyde (104-88-1) → 1-chloro-4-(2-chloroethyl)benzene (32327-70-1)

Guidance literature:

Chloroiodomethane; 4-chlorobenzaldehyde; With methyllithium lithium bromide; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

With hexylsilane; tris(pentafluorophenyl)borate; In dichloromethane; at 20 ℃; for 1h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02831

upstream raw materials:

2-(4-Chlorophenyl)ethanol

toluene-4-sulfonic acid 2-(4-chloro-phenyl)-ethyl ester

C₁₆H₁₂Cl₂O₄

N-[2-(4-chlorophenyl)ethyl]-4-methylbenzenesulfonamide

Downstream raw materials:

2-phenylethyl chloride

2-{1-[2-(4-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1H-benzoimidazole

2-(4-aminophenyl)ethyl chloride

2-(2,4-Dichlorphenyl)-4-(p-chlorphenyl)-butyronitril

Refernces

• 1、 Han, Lei,Xia, Ji-Bao,You, Lin,Chen, Chuo. "Ketone-catalyzed photochemical C(sp3)–H chlorination". . p. 3696 - 3701. Retrieved 2017/06/13.
• 2、 Nguyen, Thuy,Yang, Tianming,Go, Mei-Lin. "Functionalized acridin-9-yl phenylamines protected neuronal HT22 cells from glutamate-induced cell death by reducing intracellular levels of free radical species". supporting information. p. 1830 - 1838. Retrieved 2015/03/14.