2-(4-aminophenyl)ethyl chloride

Base Information

• Chemical Name: 2-(4-aminophenyl)ethyl chloride
• CAS No.: 81865-10-3
• Molecular Formula: C₈H₁₀ClN
• Molecular Weight: 155.627
• Mol file: 81865-10-3.mol

Synonyms:2-(4-aminophenyl)ethyl chloride

Chemical Property of 2-(4-aminophenyl)ethyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-aminophenyl)ethyl chloride

There total 8 articles about 2-(4-aminophenyl)ethyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(4-nitrophenyl)ethyl chloride (20264-95-3) → 2-(4-aminophenyl)ethyl chloride (81865-10-3)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol; for 0.166667h; under 2068.65 Torr;

DOI:10.1021/jm010924c

Reference yield:

1-chloro-4-(2-chloroethyl)benzene (32327-70-1) → 2-(4-aminophenyl)ethyl chloride (81865-10-3)

Guidance literature:

With ammonia; at 65 - 70 ℃; for 10h; under 2250.23 Torr; Temperature; Autoclave;

Reference yield:

2-phenylethyl chloride (622-24-2) → 2-(4-aminophenyl)ethyl chloride (81865-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 90 percent HNO₃ / 0.33 h / 0 °C

2: 96 percent / H₂ / 10percent Pd/C / methanol / 0.17 h / 2068.65 Torr

With hydrogen; nitric acid; 10percent Pd/C; In methanol;

DOI:10.1021/jm010924c

upstream raw materials:

ethanol

2-(4-nitrophenyl)ethyl chloride

2-phenylethyl chloride

chlorobenzene

Downstream raw materials:

YM-208876

C₁₁H₁₃ClN₂O₄S

p-hydroxyphenethyl alcohol

N-{4-[2-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-ethyl]-phenyl}-acetamide

Refernces

• 1、 Baraldi,Cacciari,Romagnoli,Spalluto,Monopoli,Ongini,Varani,Borea. "7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: A study on the importance of modifications at the side chain on the activity and solubility". . p. 115 - 126. Retrieved 2007/10/03.