Technology Process of (S,E)-4-(4-chlorophenyl)but-3-en-2-amine
There total 4 articles about (S,E)-4-(4-chlorophenyl)but-3-en-2-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridoxal 5'-phosphate; isopropylamine;
In
aq. phosphate buffer; dimethyl sulfoxide;
at 45 ℃;
for 24h;
pH=7.5;
enantioselective reaction;
Enzymatic reaction;
DOI:10.1002/cbic.201900473
- Guidance literature:
-
With
C5H11NO*CHF3O3S;
In
ethanol; water;
at 10 ℃;
for 12h;
pH=7.4;
Overall yield = 73 percent; enantioselective reaction;
Inert atmosphere;
Sealed tube;
Enzymatic reaction;
DOI:10.1021/jacs.0c03428
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen / tert-butyl methyl ether / 16 h / 30 °C / pH 5 / Enzymatic reaction
2: pyridoxal 5'-phosphate; isopropylamine / aq. phosphate buffer; dimethyl sulfoxide / 24 h / 45 °C / pH 7.5 / Enzymatic reaction
With
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; pyridoxal 5'-phosphate; oxygen; isopropylamine;
In
aq. phosphate buffer; tert-butyl methyl ether; dimethyl sulfoxide;
DOI:10.1002/cbic.201900473
