2,2,2-TRIFLUORO-2',4',6'-TRIMETHOXY-ACET OPHENONE, 98

Base Information

• Chemical Name: 2,2,2-TRIFLUORO-2',4',6'-TRIMETHOXY-ACET OPHENONE, 98
• CAS No.: 314-98-7
• Molecular Formula: C11H11 F3 O4
• Molecular Weight: 264.201
• Hs Code.: 2914700090
• Mol file: 314-98-7.mol

Synonyms:2,4,6-Trimethoxy-a,a,a-trifluoroacetophenone

Chemical Property of 2,2,2-TRIFLUORO-2',4',6'-TRIMETHOXY-ACET OPHENONE, 98

Chemical Property:

• Melting Point: 59-61 °C(lit.)
• Boiling Point: 100 °C0.1 mm Hg(lit.)
• PSA: 44.76000
• Density: 1.3244 (estimate)
• LogP: 2.45740

Purity/Quality:

97% ^*data from raw suppliers

2,2,2-Trifluoro-1-(2,4,6-trimethoxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-TRIFLUORO-2',4',6'-TRIMETHOXY-ACET OPHENONE, 98

There total 8 articles about 2,2,2-TRIFLUORO-2',4',6'-TRIMETHOXY-ACET OPHENONE, 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1,3,5-tri-O-benzylphloroglucinol (59434-20-7) + trifluoroacetic anhydride (407-25-0) + Propiolic acid (471-25-0) → (E)-1,3-di(2,4,6-trimethoxyphenyl)-2-propen-1-one (401504-46-9) + 2,2,2-trifluoro-1-(2,4,6-trimethoxyphenyl)ethan-1-one (314-98-7)

Guidance literature:

at 20 ℃; for 3h;

DOI:10.1071/CH07348

Reference yield: 15.0%

1,3,5-tri-O-benzylphloroglucinol (59434-20-7) + phenylpropyolic acid (637-44-5) + trifluoroacetic anhydride (407-25-0) → (E)-1,3-di(2,4,6-trimethoxyphenyl)-2-propen-1-one (401504-46-9) + 2,2,2-trifluoro-1-(2,4,6-trimethoxyphenyl)ethan-1-one (314-98-7)

Guidance literature:

With phenylpropyolic acid; at 20 ℃; for 3h;

DOI:10.1071/CH07348

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) + 2,4-bisbenzyloxy-3-chloro-6-methylbenzoic acid (72911-56-9) → 2,2,2-trifluoro-1-(2,4,6-trimethoxyphenyl)ethan-1-one (314-98-7) + 2,4-bisbenzyloxy-3-chloro-2',4',6'-trimethoxy-6-methylbenzophenone (74212-71-8)

Guidance literature:

With trifluoroacetic anhydride; In dichloromethane; at 0 ℃; for 0.166667h;

upstream raw materials:

2,2,2-trifluoro-1-(2,4-dihydroxy-6-methoxy-phenyl)-ethanone

dimethyl sulfate

1,2,3-trimethoxybenzene

2,4-bisbenzyloxy-3-chloro-6-methylbenzoic acid

Downstream raw materials:

2,4,6-trimethoxybenzoic acid

2,4,6-Trimethoxy-benzoic acid benzyl ester

2,4,6-Trimethoxy-benzoic acid isopropyl ester

ethyl 2,4,6-trimethoxybenzoate

Refernces

• 1、 Kerr, Penelope J.,Pyke, Simon M.,Ward, A. David. "Synthesis, and cyclization to aurones and flavones, of alkoxy-substituted aryl, arylalkynyl ketones". . p. 350 - 358. Retrieved 2008/09/19.