TRANS-2-CHLOROMETHYLVINYLBORONIC ACID

Base Information

• Chemical Name: TRANS-2-CHLOROMETHYLVINYLBORONIC ACID
• CAS No.: 215951-86-3
• Molecular Formula: C3H6 B Cl O2
• Molecular Weight: 120.343
• Hs Code.: 2931900090
• Mol file: 215951-86-3.mol

Synonyms:Boronicacid, (3-chloro-1-propenyl)- (9CI)

Chemical Property of TRANS-2-CHLOROMETHYLVINYLBORONIC ACID

Chemical Property:

• Vapor Pressure: 0.00118mmHg at 25°C
• Melting Point: 110-113 °C (dec.)(lit.)
• Refractive Index: 1.459
• Boiling Point: 266.4°C at 760 mmHg
• PKA: 9.13±0.43(Predicted)
• Flash Point: 114.9°C
• PSA: 40.46000
• Density: 1.203g/cm³
• LogP: -0.20660
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-2-Chloromethylvinylboronic acid ≥95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Reactant for Suzuki-Miyaura cross-coupling reaction. Reactant for Suzuki-Miyaura cross-coupling reaction

Technology Process of TRANS-2-CHLOROMETHYLVINYLBORONIC ACID

There total 1 articles about TRANS-2-CHLOROMETHYLVINYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-propynyl chloride (624-65-7) + benzo[1,3,2]dioxaborole (274-07-7) → (3-chloroprop-1-en-1-yl)boronic acid (215951-86-3)

Guidance literature:

With water; hydroboration and hydroylsis;;

DOI:10.1021/ja00767a072

Reference yield: 30.0%

(3-chloroprop-1-en-1-yl)boronic acid (215951-86-3) + 3-chloro-1-methoxy-4-((1-methyl-1H-1,2,4-triazol-5-yl)methyl)isoquinolin-5-amine + 1-(4-Fluorophenyl)piperazine (2252-63-3) → 3-(3-(4-(4-fluorophenyl)piperazin-1-yl)prop-1-en-1-yl)-1-methoxy-4-((1-methyl-1H-1,2,4-triazol-5-yl)methyl)isoquinolin-5-amine

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In dimethyl sulfoxide; at 120 ℃; for 24.25h;

upstream raw materials:

2-propynyl chloride

benzo[1,3,2]dioxaborole