3-Pyridinol,2-amino-4,6-dimethyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinol,2-amino-4,6-dimethyl-(9CI)
• CAS No.: 213685-57-5
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.169
• Mol file: 213685-57-5.mol

Synonyms:3-Pyridinol,2-amino-4,6-dimethyl-(9CI)

Chemical Property of 3-Pyridinol,2-amino-4,6-dimethyl-(9CI)

Chemical Property:

• Boiling Point: 335.1±42.0 °C(Predicted)
• PKA: 5.82±0.28(Predicted)
• PSA: 59.14000
• Density: 1.191±0.06 g/cm3(Predicted)
• LogP: 1.56740

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-hydroxy-4,6-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinol,2-amino-4,6-dimethyl-(9CI)

There total 5 articles about 3-Pyridinol,2-amino-4,6-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dimethyl-3-hydroxy-2-nitropyridine → 2-amino-3-hydroxy-4,6-dimethylpyridine (213685-57-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 16h;

DOI:10.1039/c6ob00244g

Reference yield:

2,4-lutidine (108-47-4) → 2-amino-3-hydroxy-4,6-dimethylpyridine (213685-57-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid; potassium nitrate / 16 h / 100 - 120 °C / Cooling with ice

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

3: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C / Reflux

4: ammonium cerium (IV) nitrate; sodium hydrogencarbonate / acetonitrile / 6 h / 20 °C / Reflux

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C

With ammonium cerium (IV) nitrate; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; potassium nitrate; sodium nitrite; In methanol; water; ethyl acetate; acetonitrile;

DOI:10.1039/c6ob00244g

Reference yield:

2,4-dimethyl-5-nitropyridine (1074-99-3) → 2-amino-3-hydroxy-4,6-dimethylpyridine (213685-57-5)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

2: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C / Reflux

3: ammonium cerium (IV) nitrate; sodium hydrogencarbonate / acetonitrile / 6 h / 20 °C / Reflux

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C

With ammonium cerium (IV) nitrate; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; sodium nitrite; In methanol; water; ethyl acetate; acetonitrile;

DOI:10.1039/c6ob00244g

upstream raw materials:

2,4-lutidine

2,4-dimethyl-5-nitropyridine

5-amino-2,4-dimethylpyridine

2,4-dimethyl-5-hydroxypyridine

Refernces